Symbyax and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Symbyax (fluoxetine hydrochloride; olanzapine) and Tylenol (acetaminophen). Common drug interactions include agitation among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Symbyax and Tylenol. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Symbyax?

Symbyax has active ingredients of fluoxetine hydrochloride; olanzapine. It is often used in depression. eHealthMe is studying from 1,449 Symbyax users. Check the latest studies of Symbyax.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

19 people who take Symbyax and Tylenol together, and have interactions are studied.

What are the common drug interactions of Symbyax and Tylenol, by gender? *:

female:

Agitation (state of anxiety or nervous excitement)
Blood pressure increased
Body temperature increased
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic villitis of unknown etiology (infection of placenta by unknown origination)
Coma (state of unconsciousness lasting more than six hours)
Depressed level of consciousness
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

male:

Aggression
Anxiety
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Insomnia (sleeplessness)
Loss of consciousness
Mood altered (changes in mood)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Obesity (having too much body fat)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

What are the common drug interactions of Symbyax and Tylenol, by age (0-1 to 60+)? *:

0-1:

Arrhythmia (irregular heartbeat)

2-9:

n/a

10-19:

n/a

20-29:

Insomnia (sleeplessness)
Overdose
Abdominal pain upper
Abscess (pus)
Cellulitis (infection under the skin)
Depressed level of consciousness
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug hypersensitivity
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)

30-39:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hallucination (an experience involving the perception of something not present)
Hepatic failure (liver failure)
Influenza like illness
Insomnia (sleeplessness)
Overdose
Productive cough
Pyrexia (fever)
Suicidal ideation
Weight decreased

40-49:

Acute respiratory failure
Alanine aminotransferase increased
Aspartate aminotransferase increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypokalaemia (low potassium)
Laryngeal oedema (swelling of larynx)
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Urinary tract infection

50-59:

Crying
Disturbance in attention
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Heart rate increased
Hunger
Insomnia (sleeplessness)
Merycism (a rare disease in which food is chewed, swallowed, and then returned to the mouth and chewed again)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

60+:

Aggression
Anxiety
Arrhythmia (irregular heartbeat)
Insomnia (sleeplessness)
Mood altered (changes in mood)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 8 people, 42.11%
Stress And Anxiety: 7 people, 36.84%
High Blood Pressure: 6 people, 31.58%
Sleep Disorder: 5 people, 26.32%
Nausea (feeling of having an urge to vomit): 5 people, 26.32%
Bipolar Disorder (mood disorder): 4 people, 21.05%
Indigestion: 3 people, 15.79%
Constipation: 3 people, 15.79%
Breast Cancer Female: 3 people, 15.79%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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