Synjardy xr and Lantus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synjardy xr (empagliflozin; metformin hydrochloride) and Lantus (insulin glargine recombinant). Common drug interactions include alopecia among females and ingrowing nail among males.

The phase IV clinical study analyzes what interactions people have when they take Synjardy xr and Lantus. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Synjardy xr?

Synjardy xr has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 564 Synjardy xr users. Check the latest studies of Synjardy xr.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.



On Jul, 20, 2026

16 people who take Synjardy xr and Lantus together, and have interactions are studied.

Synjardy xr and Lantus drug interactions.

What are the common drug interactions of Synjardy Xr and Lantus, by gender? *:

female:

  1. Alopecia (absence of hair from areas of the body)
  2. Blood pressure increased
  3. Dysphonia (speech disorder attributable to a disorder of phonation)
  4. Fatigue (feeling of tiredness)
  5. Diarrhoea
  6. Glossitis (infection of tongue with soreness)
  7. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  8. Rash
  9. Anxiety
  10. Choking (mechanical obstruction of the flow of air from the environment into the lungs)

male:

  1. Ingrowing nail
  2. Localised infection (infection at the single location)
  3. Multiple allergies (allergy to multiple agents)
  4. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  5. Non-small cell lung cancer (type of epithelial lung cancer)
  6. Pericardial effusion (fluid around the heart)
  7. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  8. Small cell lung cancer (small cell cancer tumour of lung)
  9. Coronary arterial stent insertion
  10. Dysuria (painful or difficult urination)

What are the common drug interactions of Synjardy Xr and Lantus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Ingrowing nail
  2. Localised infection (infection at the single location)
  3. Nasopharyngitis (inflammation of the nasopharynx)
  4. Seasonal allergy (allergic condition due to certain season)
  5. Sinus congestion (blockage of sinus)
  6. Fatigue (feeling of tiredness)
  7. Arrhythmia (irregular heartbeat)
  8. Cardiac arrest
  9. Cardiac pacemaker replacement
  10. Hypersensitivity

60+:

  1. Alopecia (absence of hair from areas of the body)
  2. Blood pressure increased
  3. Choking (mechanical obstruction of the flow of air from the environment into the lungs)
  4. Depression
  5. Dysphagia (a condition in which swallowing is difficult or painful)
  6. Hair colour changes
  7. Hair disorder
  8. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  9. Penile erythema (redness on penis)
  10. Penile infection

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 5 people, 31.25%
  2. Stress And Anxiety: 2 people, 12.50%
  3. Renal Cell Carcinoma (a kidney cancer): 2 people, 12.50%
  4. Pneumonia: 2 people, 12.50%
  5. Pain: 2 people, 12.50%
  6. Nausea (feeling of having an urge to vomit): 2 people, 12.50%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 12.50%
  8. Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 2 people, 12.50%
  9. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 12.50%
  10. Cough: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Synjardy xr and Lantus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Synjardy xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lantus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Synjardy xr and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lantus and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on empagliflozin; metformin hydrochloride and insulin glargine recombinant (the active ingredients of Synjardy xr and Lantus, respectively), and Synjardy xr and Lantus (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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