Synjardy and Januvia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synjardy (empagliflozin; metformin hydrochloride) and Januvia (sitagliptin phosphate). Common drug interactions include tremor among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Synjardy and Januvia. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

51 people who take Synjardy and Januvia together, and have interactions are studied.

What are the common drug interactions of Synjardy and Januvia, by gender? *:

female:

Tremor (trembling or shaking movements in one or more parts of your body)
Vein disorder
White blood cell count decreased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood iron decreased
Dizziness
Drug hypersensitivity
Drug ineffective

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Fatigue (feeling of tiredness)
Loss of consciousness
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Psoriasis (immune-mediated disease that affects the skin)
Renal impairment (severely reduced kidney function)
Sinusitis (inflammation of sinus)
Alopecia (absence of hair from areas of the body)
Blindness

What are the common drug interactions of Synjardy and Januvia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Depression
Emotional distress
Fatigue (feeling of tiredness)
Pain
Blood creatinine increased
Overdose

40-49:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Chronic kidney disease
Depression
Emotional distress
Pain
Renal impairment (severely reduced kidney function)

60+:

Dizziness
Loss of consciousness
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Deafness unilateral
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dry skin
Dyspnoea (difficult or laboured respiration)
Fall

What are the existing conditions these people have? *

Type 2 Diabetes: 16 people, 31.37%
High Blood Pressure: 7 people, 13.73%
Multiple Myeloma (cancer of the plasma cells): 5 people, 9.80%
High Blood Cholesterol: 5 people, 9.80%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 7.84%
Hiv Infection: 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

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