Tafinlar and Movicol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tafinlar (dabrafenib mesylate) and Movicol (polyethylene glycol 3350). Common drug interactions include upper gastrointestinal haemorrhage among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Tafinlar and Movicol. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Tafinlar?

Tafinlar has active ingredients of dabrafenib mesylate. eHealthMe is studying from 16,304 Tafinlar users. Check the latest studies of Tafinlar.

What is Movicol?

Movicol has active ingredients of polyethylene glycol 3350. It is often used in constipation. eHealthMe is studying from 14,249 Movicol users. Check the latest studies of Movicol.

On Jul, 09, 2026

39 people who take Tafinlar and Movicol together, and have interactions are studied.

What are the common drug interactions of Tafinlar and Movicol, by gender? *:

female:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Malignant neoplasm progression (cancer tumour came back)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Myalgia (muscle pain)
Dry skin
Ageusia (loss of taste functions of the tongue)
Arthralgia (joint pain)

male:

Arthralgia (joint pain)
Asthenia (weakness)
Gastroenteritis (inflammation of stomach and intestine)
General physical health deterioration (weak health status)
Herpes zoster
Hyperkalaemia (damage to or disease of the kidney)
Influenza like illness
Meningioma malignant (cancerous tumour of membranes that cover the brain and spinal cord just inside the skull)
Neuropathy peripheral (surface nerve damage)
Pain in extremity

What are the common drug interactions of Tafinlar and Movicol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Electrocardiogram st segment elevation
Electrocardiogram t wave peaked
Troponin increased

20-29:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatocellular injury (liver injury)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Pyrexia (fever)
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Pain in extremity
Vision blurred
Alopecia (absence of hair from areas of the body)
Blood creatine phosphokinase increased

30-39:

n/a

40-49:

Abdominal pain
Malignant neoplasm progression (cancer tumour came back)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Dry skin
Ageusia (loss of taste functions of the tongue)
Arthralgia (joint pain)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Abdominal pain lower

50-59:

Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacteraemia (presence of bacteria in the blood)
Brain neoplasm malignant (brain cancer tumour)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dehydration (dryness resulting from the removal of water)
Diarrhoea haemorrhagic (bloody diarrhoea)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Erysipelas (bacterial skin infection)
Gastroenteritis (inflammation of stomach and intestine)

60+:

Pyrexia (fever)
Malignant neoplasm progression (cancer tumour came back)
Fatigue (feeling of tiredness)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to liver (cancer spreads to liver)
Metastases to peritoneum (cancer spreads to peritoneum)
Nausea (feeling of having an urge to vomit)
Renal injury (kidney injury)
Blood lactate dehydrogenase increased

What are the existing conditions these people have? *

Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 32 people, 82.05%
Malignant Melanoma (skin cancer rises from melancytes): 26 people, 66.67%
Depressed Mood: 16 people, 41.03%
Pain: 15 people, 38.46%
Depression: 12 people, 30.77%
Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 10 people, 25.64%
High Blood Pressure: 9 people, 23.08%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 10.26%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 10.26%
Abdominal Pain: 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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