Tagamet and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tagamet (cimetidine) and Melatonin (melatonin). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tagamet and Melatonin. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Tagamet?

Tagamet has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,011 Tagamet users. Check the latest studies of Tagamet.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

78 people who take Tagamet and Melatonin together, and have interactions are studied.

Tagamet and Melatonin drug interactions.

What are the common drug interactions of Tagamet and Melatonin, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Drug ineffective
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Disturbance in attention
Fatigue (feeling of tiredness)
Full blood count decreased
Full blood count increased
Infection
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Platelet count decreased
Pneumonia

What are the common drug interactions of Tagamet and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Chronic kidney disease
Drug ineffective
Hospitalisation
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)

30-39:

Chronic kidney disease
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Intervertebral disc degeneration (spinal disc degeneration)
Muscle atrophy (a decrease in the mass of the muscle)
Nerve compression
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Death
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diabetic nephropathy (diabetic kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
Disturbance in attention

60+:

Chronic kidney disease
Drug ineffective
Speech disorder
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Blood immunoglobulin g decreased
Cardiac disorder
Disease progression
Dyspnoea (difficult or laboured respiration)
Full blood count decreased
Full blood count increased

What are the existing conditions these people have? *

Pain: 41 people, 52.56%
High Blood Pressure: 27 people, 34.62%
Sleep Disorder: 24 people, 30.77%
Stress And Anxiety: 18 people, 23.08%
Depression: 17 people, 21.79%
High Blood Cholesterol: 16 people, 20.51%
Neuralgia (pain in one or more nerves): 11 people, 14.10%
Infection: 10 people, 12.82%
Indigestion: 10 people, 12.82%
Diabetes: 9 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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