Talwin and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Talwin (pentazocine lactate) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include osteochondrosis among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Talwin and Vicodin. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Talwin?

Talwin has active ingredients of pentazocine lactate. It is often used in pain. eHealthMe is studying from 893 Talwin users. Check the latest studies of Talwin.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 14, 2026

76 people who take Talwin and Vicodin together, and have interactions are studied.

What are the common drug interactions of Talwin and Vicodin, by gender? *:

female:

Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Anxiety
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Urinary tract infection
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Weight decreased
Blood pressure increased
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Intervertebral disc protrusion (spinal disc protrusion)
Accident at work
Bipolar disorder (mood disorder)
Hypotension (abnormally low blood pressure)
Nodal rhythm (40-50 beats per minute)
Ventricular fibrillation (abnormally irregular heart rhythm)
Acute respiratory failure

What are the common drug interactions of Talwin and Vicodin, by age (0-1 to 60+)? *:

0-1:

Amblyopia (lazy eye)
Autism spectrum disorder (developmental disabilities that can cause significant social, communication and behavioural challenges)
Constipation
Developmental delay
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotonia (low muscle tone)
Lactose intolerance (inability to digest lactose)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

2-9:

n/a

10-19:

Arthralgia (joint pain)
Rash
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Drug hypersensitivity
Rash erythematous (redness of the skin)
Blood albumin decreased
Blood calcium decreased
Blood urea decreased
Fatigue (feeling of tiredness)
Gallbladder disorder

20-29:

Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Chlamydial infection (a common sexually transmitted infection (sti) in humans caused by the bacterium chlamydia trachomatis)
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gestational diabetes (diabetes in pregnancy)
Ketoacidosis (high concentrations of ketone bodies in blood)
Maternal exposure during pregnancy (use of substance during pregnancy)
Nausea (feeling of having an urge to vomit)
Premature labour
Restlessness (not able to rest)

30-39:

Hypoaesthesia (reduced sense of touch or sensation)
Asthenia (weakness)
Blood cholesterol increased
Chest discomfort
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Complex partial seizures (epileptic seizure)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Dysarthria (speech disorder)
Facial palsy (paralysis of face nerve)

40-49:

Bone disorder
Arthralgia (joint pain)
Aseptic necrosis bone
Drug hypersensitivity
Ileus (a painful obstruction of the ileum or other part of the intestine)
Anxiety
Diarrhoea
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Alopecia (absence of hair from areas of the body)

50-59:

Ejection fraction decreased (systolic heart failure)
Implant site erythema (redness at implant site)
Implant site swelling
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Respiratory rate increased (excess breathing rate/min)
Spinal column stenosis (narrowing of spinal column)
Spinal osteoarthritis (joint cartilage loss in spine)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Testicular disorder (disease of testes)
Blood pressure increased

60+:

Drug hypersensitivity
Chest discomfort
Urticaria (rash of round, red welts on the skin that itch intensely)
Central nervous system stimulation
Delirium (wild excitement)
Depressed level of consciousness
Depression
Difficulty in walking
Digoxin toxicity
Drug ineffective

What are the existing conditions these people have? *

Pain In Extremity: 10 people, 13.16%
High Blood Pressure: 10 people, 13.16%
Back Pain: 5 people, 6.58%

* Approximation only. Some reports may have incomplete information.

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