Tapentadol and Gemcitabine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tapentadol (tapentadol) and Gemcitabine (gemcitabine). Common drug interactions include asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Tapentadol and Gemcitabine. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Tapentadol?

Tapentadol has active ingredients of tapentadol. It is often used in chronic pain. eHealthMe is studying from 2,551 Tapentadol users. Check the latest studies of Tapentadol.

What is Gemcitabine?

Gemcitabine has active ingredients of gemcitabine. eHealthMe is studying from 31,337 Gemcitabine users. Check the latest studies of Gemcitabine.

On Jul, 11, 2026

14 people who take Tapentadol and Gemcitabine together, and have interactions are studied.

Tapentadol and Gemcitabine drug interactions.

What are the common drug interactions of Tapentadol and Gemcitabine, by gender? *:

female:

n/a

male:

Asthenia (weakness)
Diarrhoea
Eating disorder
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Bacterial sepsis
Blood creatinine increased
Decreased appetite

What are the common drug interactions of Tapentadol and Gemcitabine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Enterococcal sepsis
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Bacterial sepsis

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Asthenia (weakness)
Decreased appetite
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Asthenia (weakness)
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Blood creatinine increased
Febrile neutropenia (fever with reduced white blood cells)
Large intestine perforation (hole in large intestine)
Myelosuppression (a decrease in the production of blood cells)
Syncope (loss of consciousness with an inability to maintain postural tone)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Pain: 7 people, 50.00%
Constipation: 6 people, 42.86%
Nausea (feeling of having an urge to vomit): 5 people, 35.71%
Nausea And Vomiting: 5 people, 35.71%
Insomnia (sleeplessness): 4 people, 28.57%
Febrile Neutropenia (fever with reduced white blood cells): 3 people, 21.43%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 3 people, 21.43%
Fever: 3 people, 21.43%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 21.43%
Generalised Oedema (swelling all over the body): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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