Tarka and Dyazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tarka (trandolapril; verapamil hydrochloride) and Dyazide (hydrochlorothiazide; triamterene). Common drug interactions include blood alkaline phosphatase decreased among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Tarka and Dyazide. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Tarka?

Tarka has active ingredients of trandolapril; verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,409 Tarka users. Check the latest studies of Tarka.

What is Dyazide?

Dyazide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 11,506 Dyazide users. Check the latest studies of Dyazide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

13 people who take Tarka and Dyazide together, and have interactions are studied.

What are the common drug interactions of Tarka and Dyazide, by gender? *:

female:

Blood alkaline phosphatase decreased
Blood creatinine increased
Blood urea increased
Monocyte count increased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Platelet count decreased
Red blood cell count decreased
White blood cell count decreased
Abdominal distension

male:

Abdominal pain upper
Blood glucose fluctuation
Blood pressure fluctuation
Diabetes mellitus insulin-dependent
Headache (pain in head)
Impotence (powerlessness)
Jaundice cholestatic
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Weight decreased

What are the common drug interactions of Tarka and Dyazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood cholesterol increased
Blood creatine phosphokinase increased
Blood triglycerides increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Diabetes mellitus non-insulin-dependent
Hypertensive crisis
Hypoglycaemia (deficiency of glucose in the bloodstream)
Low density lipoprotein increased (cholesterol increased in blood)

50-59:

Lipase increased
Pancreatitis (inflammation of pancreas)
Steatorrhoea (presence of excess fat in faeces)
Abdominal pain upper

60+:

Blood alkaline phosphatase decreased
Blood creatinine increased
Cardiomegaly (increased size of heart than normal)
Fall
Foot fracture
Heart rate decreased
Heart rate irregular
Mean cell volume increased (more than normal average red blood cell volume)
Wound
Abdominal pain upper

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 3 people, 23.08%
Weight Loss: 2 people, 15.38%
Joint Swelling: 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 2 people, 15.38%
Asthma: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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