Tarka and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tarka (trandolapril; verapamil hydrochloride) and Prolia (denosumab). Common drug interactions include ankle fracture among females and ankle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Tarka and Prolia. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Tarka?

Tarka has active ingredients of trandolapril; verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,409 Tarka users. Check the latest studies of Tarka.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

12 people who take Tarka and Prolia together, and have interactions are studied.

What are the common drug interactions of Tarka and Prolia, by gender? *:

female:

Ankle fracture
Bone density decreased
Bone loss
Emotional distress
Foot fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Rib fracture
Vitamin d deficiency
Fall
Intervertebral disc degeneration (spinal disc degeneration)

male:

Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fibromyalgia (a long-term condition which causes pain all over the body)
Fibula fracture
Foot fracture
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Joint injury
Multiple fractures
Neck pain

What are the common drug interactions of Tarka and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Ankle fracture
Bone density decreased
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Coccydynia (pain in the coccyx or tailbone area)
Erythema (redness of the skin)
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Joint effusion (presence of extra fluid in joint covering)
Joint swelling
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Migraine (headache): 9 people, 75.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 75.00%
Pain: 8 people, 66.67%
Bone Disorder: 8 people, 66.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Radiculitis Lumbosacral (inflammation of nerve root at labosacral vertebrea): 1 person, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 8.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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