Tecfidera and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Arava (leflunomide). Common drug interactions include joint swelling among females.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Arava. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Jul, 19, 2026

53 people who take Tecfidera and Arava together, and have interactions are studied.

What are the common drug interactions of Tecfidera and Arava, by gender? *:

female:

Joint swelling
Lower respiratory tract infection
Ear pain
Insomnia (sleeplessness)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Night sweats (sweating in night)
Pruritus (severe itching of the skin)
Rash
Synovitis (inflammation of the synovial membrane)
Urticaria (rash of round, red welts on the skin that itch intensely)

male:

n/a

What are the common drug interactions of Tecfidera and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Joint swelling
Lower respiratory tract infection
Pain
Sinusitis (inflammation of sinus)
Peripheral swelling
Asthenia (weakness)
Back pain
Body temperature increased
Diarrhoea
Ear pain

50-59:

n/a

60+:

Anaphylactic reaction (serious allergic reaction)
Hypersensitivity
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Abdominal discomfort
Balance disorder
Dizziness
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Diarrhea: 35 people, 66.04%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 14 people, 26.42%
Psoriasis (immune-mediated disease that affects the skin): 14 people, 26.42%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 14 people, 26.42%
Ankylosing Spondylitis (type of arthritis affecting the spine): 14 people, 26.42%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 11.32%

* Approximation only. Some reports may have incomplete information.

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