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Tecfidera and Lotemax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Lotemax (loteprednol etabonate). Common drug interactions include macular oedema among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Lotemax. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Lotemax?

Lotemax has active ingredients of loteprednol etabonate. It is often used in inflammation. eHealthMe is studying from 4,431 Lotemax users. Check the latest studies of Lotemax.

On Jul, 06, 2026

22 people who take Tecfidera and Lotemax together, and have interactions are studied.

Tecfidera and Lotemax drug interactions.

What are the common drug interactions of Tecfidera and Lotemax, by gender? *:

female:

  1. Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
  2. White blood cell count decreased
  3. Decreased interest
  4. Fall
  5. Hyperhidrosis (abnormally increased sweating)
  6. Burning sensation
  7. Nasopharyngitis (inflammation of the nasopharynx)
  8. Osteomalacia (softening of the bones due to a lack of vitamin d)
  9. Breast enlargement
  10. Dyspnoea (difficult or laboured respiration)

male:

  1. Death
  2. Post procedural infection

What are the common drug interactions of Tecfidera and Lotemax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Visual impairment

40-49:

n/a

50-59:

  1. Flushing (the warm, red condition of human skin)
  2. Nausea (feeling of having an urge to vomit)
  3. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  4. Insomnia (sleeplessness)
  5. Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
  6. White blood cell count decreased
  7. Burning sensation
  8. Diarrhoea
  9. Dizziness
  10. Fatigue (feeling of tiredness)

60+:

  1. Depression
  2. Ankle fracture
  3. Dyspnoea (difficult or laboured respiration)
  4. Muscle spasms (muscle contraction)
  5. Weight decreased
  6. Abdominal pain upper
  7. Depressed mood
  8. Feeling of despair
  9. General symptom
  10. Hot flush (sudden feelings of heat)

What are the existing conditions these people have? *

  1. Gait Disturbance: 6 people, 27.27%

* Approximation only. Some reports may have incomplete information.

Do you take Tecfidera and Lotemax?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tecfidera and Lotemax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tecfidera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lotemax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tecfidera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lotemax and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on dimethyl fumarate and loteprednol etabonate (the active ingredients of Tecfidera and Lotemax, respectively), and Tecfidera and Lotemax (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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