Tecfidera and Narcan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Narcan (naloxone hydrochloride). Common drug interactions include abdominal distension among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Narcan. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

32 people who take Tecfidera and Narcan together, and have interactions are studied.

What are the common drug interactions of Tecfidera and Narcan, by gender? *:

female:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Alopecia (absence of hair from areas of the body)

male:

Fatigue (feeling of tiredness)
Pancreatic carcinoma (pancreatic cancer)
Post-traumatic stress disorder
Altered state of consciousness (altered state of mind)
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Drooling (drop saliva uncontrollably from the mouth)
Mobility decreased (ability to move is reduced)
Overdose
Speech disorder

What are the common drug interactions of Tecfidera and Narcan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Alopecia (absence of hair from areas of the body)

50-59:

Fall
Mobility decreased (ability to move is reduced)
Sleep disorder
Joint dislocation (a joint position is changed from normal position)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Brain neoplasm (tumour of brain)
Drug ineffective
Fatigue (feeling of tiredness)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)

60+:

Pneumonia

What are the existing conditions these people have? *

Pain: 6 people, 18.75%
Gait Disturbance: 4 people, 12.50%
Depression: 4 people, 12.50%
Migraine Without Aura (headache without neurological problems): 3 people, 9.38%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 9.38%
Muscle Spasms (muscle contraction): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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