Tecfidera and Vitamin d2 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Vitamin d2 (ergocalciferol). Common drug interactions include depression among females and stress among males.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Vitamin d2. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Vitamin d2?

Vitamin d2 has active ingredients of ergocalciferol. eHealthMe is studying from 979 Vitamin d2 users. Check the latest studies of Vitamin d2.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 16, 2026

16 people who take Tecfidera and Vitamin d2 together, and have interactions are studied.

Tecfidera and Vitamin d2 drug interactions.

What are the common drug interactions of Tecfidera and Vitamin D2, by gender? *:

female:

  1. Depression
  2. Hepatic enzyme increased
  3. Hypertension (high blood pressure)
  4. Migraine (headache)
  5. Osteopenia (a condition where bone mineral density is lower than normal)
  6. Abdominal pain upper
  7. Arthropathy
  8. Asthenia (weakness)
  9. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  10. Balance disorder

male:

  1. Stress
  2. Insomnia (sleeplessness)
  3. Night sweats (sweating in night)
  4. Throat irritation

What are the common drug interactions of Tecfidera and Vitamin D2, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anxiety
  2. Insomnia (sleeplessness)

50-59:

  1. Pain
  2. Affect lability (emotional incontinence)
  3. Abdominal pain upper
  4. Asthenia (weakness)
  5. Balance disorder
  6. Cervical cord compression (compression of spinal cord at site of cervical vertebrae)
  7. Chest discomfort
  8. Dizziness
  9. Drug ineffective
  10. Flushing (the warm, red condition of human skin)

60+:

n/a

What are the existing conditions these people have? *

  1. Gait Disturbance: 3 people, 18.75%
  2. Stress And Anxiety: 2 people, 12.50%
  3. Nausea (feeling of having an urge to vomit): 2 people, 12.50%
  4. Muscle Spasms (muscle contraction): 2 people, 12.50%
  5. Nausea And Vomiting: 1 person, 6.25%
  6. High Blood Pressure: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Tecfidera and Vitamin d2?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tecfidera and Vitamin d2:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tecfidera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vitamin d2:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tecfidera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vitamin d2 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on dimethyl fumarate and ergocalciferol (the active ingredients of Tecfidera and Vitamin d2, respectively), and Tecfidera and Vitamin d2 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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