Tegretol and Propulsid drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tegretol (carbamazepine) and Propulsid (cisapride monohydrate). Common drug interactions include depression among females and dyspnoea among males.
The phase IV clinical study analyzes what interactions people have when they take Tegretol and Propulsid. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.
What is Tegretol?
Tegretol has active ingredients of carbamazepine. It is often used in epilepsy. eHealthMe is studying from 45,969 Tegretol users. Check the latest studies of Tegretol.
What is Propulsid?
Propulsid has active ingredients of cisapride monohydrate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 8,130 Propulsid users. Check the latest studies of Propulsid.
74 people who take Tegretol and Propulsid together, and have interactions are studied.

What are the common drug interactions of Tegretol and Propulsid, by gender? *:
female:
- Depression
- Drug hypersensitivity
- Drug ineffective
- Nausea (feeling of having an urge to vomit)
- Oedema lower limb (fluid collection in tissue of lower leg)
- Pyrexia (fever)
- Apnoea (suspension of external breathing)
- Arrhythmia (irregular heartbeat)
- Cardiac arrest
- Confusion
male:
- Dyspnoea (difficult or laboured respiration)
- Hypoxia (low oxygen in tissues)
- Arthralgia (joint pain)
- Asthenia (weakness)
- Electrocardiogram qt prolonged
- Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)
- Headache (pain in head)
- Malaise (a feeling of general discomfort or uneasiness)
- Pain
- Palpitations (feelings or sensations that your heart is pounding or racing)
What are the common drug interactions of Tegretol and Propulsid, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Drug maladministration
- Pyrexia (fever)
- Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
- Palpitations (feelings or sensations that your heart is pounding or racing)
- Apnoea (suspension of external breathing)
- Arrhythmia (irregular heartbeat)
- Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
- Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
- Diarrhoea
- Dyspnoea (difficult or laboured respiration)
10-19:
- Acute circulatory failure (shock)
- Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)
- Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
- Asthenia (weakness)
- Crying
- Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
- Muscle spasms (muscle contraction)
- Opisthotonus (a condition in which the body is held in an abnormal position)
- Pain
- Pallor
20-29:
- Hypoxia (low oxygen in tissues)
- Pyrexia (fever)
- Abdominal pain
- Adult respiratory distress syndrome (type of lung (pulmonary) failure)
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
- Asthenia (weakness)
- Asthma
- Ataxia (loss of full control of bodily movements)
- Bacterial infection
- Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
30-39:
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
- Cardiac murmur (an heart sound in valve abnormality)
- Dyspnoea (difficult or laboured respiration)
- Palpitations (feelings or sensations that your heart is pounding or racing)
- Oedema lower limb (fluid collection in tissue of lower leg)
- Blood sodium increased
- Agitation (state of anxiety or nervous excitement)
- Confusion
- Depression
40-49:
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Cardiac failure congestive
- Conjunctivitis (pink eye)
- Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
- Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
- Hypotension (abnormally low blood pressure)
- Insomnia (sleeplessness)
- Lip ulceration (ulcer of lip)
- Pyrexia (fever)
- Upper respiratory tract infection
50-59:
- Pressure sore
- Pulse absent
- Renal failure (kidney dysfunction)
- Retinopathy proliferative (a condition in which very small blood vessels grow from the surface of the retina and damages retina)
- Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
- Speech disorder
- Suicide attempt
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Urinary retention (the inability to completely or partially empty the bladder)
- Weight increased
60+:
- Adult respiratory distress syndrome (type of lung (pulmonary) failure)
- Dyspnoea (difficult or laboured respiration)
- Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
- Electrocardiogram qt prolonged
- Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
- Headache (pain in head)
- Malaise (a feeling of general discomfort or uneasiness)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Nausea (feeling of having an urge to vomit)
- Peripheral neuropathy (damage to nerves of the peripheral nervous system)
* Approximation only. Some reports may have incomplete information.
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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Tegretol and Propulsid:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tegretol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Propulsid:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tegretol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Propulsid and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Puvanendran R, Teo HZ, "Case report of use of Black Cohosh for carbamazepine induced hot flushes in a post menopausal woman", Maturitas, 2017 Jun .
- Arshad F, Ladakhi Y, Khan MA, "A rare case of carbamazepine induced pancreatitis", International Journal of Students’ Research, 2013 Jul .
- Yava?o?lu I, Sarg?n G, Demirbulat A, "Carbamazepine and hematological malignancies", Turkish journal of haematology: official journal of Turkish Society of Haematology, 2013 Jan .
- Puvanendran R, Teo HZ, "Case report of use of Black Cohosh for carbamazepine induced hot flushes in a post menopausal woman", Maturitas, 2017 Jun .
- Arshad F, Ladakhi Y, Khan MA, "A rare case of carbamazepine induced pancreatitis", International Journal of Students’ Research, 2013 Jul .
- Yava?o?lu I, Sarg?n G, Demirbulat A, "Carbamazepine and hematological malignancies", Turkish journal of haematology: official journal of Turkish Society of Haematology, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on carbamazepine and cisapride monohydrate (the active ingredients of Tegretol and Propulsid, respectively), and Tegretol and Propulsid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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