Tegretol and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tegretol (carbamazepine) and Saphris (asenapine maleate). Common drug interactions include movement disorder among females and withdrawal syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Tegretol and Saphris. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Tegretol?

Tegretol has active ingredients of carbamazepine. It is often used in epilepsy. eHealthMe is studying from 45,969 Tegretol users. Check the latest studies of Tegretol.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

81 people who take Tegretol and Saphris together, and have interactions are studied.

What are the common drug interactions of Tegretol and Saphris, by gender? *:

female:

Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pseudodementia (severe form of depression that results from a progressive brain disorder in which cognitive changes mimic those of dementia)
Sleep disorder
Suicide attempt
Toothache (tooth pain)
Weight decreased
Death
Dysgeusia (disorder of the sense of taste)
Gingival pain (gum pain)

male:

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Back disorder
Cat scratch disease (bacterial infection by cat scratch)
Coma (state of unconsciousness lasting more than six hours)
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Dyskinesia (abnormality or impairment of voluntary movement)
Hyposmia (impairment of the sense of smell)
Increased appetite
Nephrolithiasis (calculi in the kidneys)
Neuralgia (pain in one or more nerves)

What are the common drug interactions of Tegretol and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Sedation

20-29:

Back pain
Cat scratch disease (bacterial infection by cat scratch)
Coma (state of unconsciousness lasting more than six hours)
Constipation
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Hyposmia (impairment of the sense of smell)
Impaired gastric emptying
Increased appetite

30-39:

Partial seizures (seizures which affect only a part of the brain at onset)
Rash generalised (rash on most of body parts)
Rash pruritic (redness with itching)
Sedation
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tendon injury
Throat tightness
Tooth discolouration (a change in colour of teeth)
Visual impairment

40-49:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Fatigue (feeling of tiredness)
Foot fracture
Fungal infection
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Pruritus generalised (generalized itching)
Urinary retention (the inability to completely or partially empty the bladder)
Vision blurred
Vomiting

50-59:

Disturbance in attention
Confusional state
Vision blurred
Fall
Back disorder
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Pain
Rash
Road traffic accident

60+:

Dizziness
Abdominal discomfort
Gait disturbance
Heart rate decreased
Hospitalisation
Intervertebral disc protrusion (spinal disc protrusion)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pharyngeal disorder
Psoriasis (immune-mediated disease that affects the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 37.04%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 29 people, 35.80%
Insomnia (sleeplessness): 14 people, 17.28%
Bipolar Disorder (mood disorder): 12 people, 14.81%
Stress And Anxiety: 8 people, 9.88%
Pain: 8 people, 9.88%
Sleep Disorder: 6 people, 7.41%
Drowsiness: 6 people, 7.41%
Depression: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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