Tegretol and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tegretol (carbamazepine) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include intervertebral disc protrusion among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Tegretol and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Tegretol?

Tegretol has active ingredients of carbamazepine. It is often used in epilepsy. eHealthMe is studying from 45,969 Tegretol users. Check the latest studies of Tegretol.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.



On Jul, 06, 2026

13 people who take Tegretol and Valacyclovir hydrochloride together, and have interactions are studied.

Tegretol and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Tegretol and Valacyclovir Hydrochloride, by gender? *:

female:

  1. Intervertebral disc protrusion (spinal disc protrusion)
  2. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  3. Syncope (loss of consciousness with an inability to maintain postural tone)
  4. Diarrhoea
  5. Hypertension (high blood pressure)
  6. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  7. Sinusitis (inflammation of sinus)
  8. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  9. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  10. Vomiting

male:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Cellulitis (infection under the skin)
  3. Confusional state
  4. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the common drug interactions of Tegretol and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  4. Cytolytic hepatitis (dissolution or destruction of a liver cell)
  5. Aspartate aminotransferase decreased
  6. Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
  7. C-reactive protein increased
  8. Gamma-glutamyltransferase increased
  9. Haemodilution (increase in the volume of plasma in relation to red blood cells)
  10. Haemoglobin decreased

30-39:

  1. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  2. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

40-49:

n/a

50-59:

  1. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  2. Sinusitis (inflammation of sinus)
  3. Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

  1. Diarrhoea
  2. Hypertension (high blood pressure)
  3. Atrioventricular block second degree (heart block second degree)
  4. Back pain
  5. Balance disorder
  6. Blood cholesterol increased
  7. Blood pressure increased
  8. Brain death
  9. Cardiac disorder
  10. Carotid artery stenosis (narrowing of carotid artery)

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 23.08%
  2. Drowsiness: 3 people, 23.08%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 23.08%
  4. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 23.08%
  5. Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 7.69%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%
  7. Cellulitis (infection under the skin): 1 person, 7.69%
  8. Diarrhea: 1 person, 7.69%
  9. Fever: 1 person, 7.69%
  10. Fungal Infection: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tegretol and Valacyclovir hydrochloride:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tegretol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tegretol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valacyclovir hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on carbamazepine and valacyclovir hydrochloride (the active ingredients of Tegretol and Valacyclovir hydrochloride, respectively), and Tegretol and Valacyclovir hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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