Tekturna and Klonopin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tekturna (aliskiren hemifumarate) and Klonopin (clonazepam). Common drug interactions include malaise among females and asthenia among males.
The phase IV clinical study analyzes what interactions people have when they take Tekturna and Klonopin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.
What is Tekturna?
Tekturna has active ingredients of aliskiren hemifumarate. It is often used in high blood pressure. eHealthMe is studying from 4,730 Tekturna users. Check the latest studies of Tekturna.
What is Klonopin?
Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.
22 people who take Tekturna and Klonopin together, and have interactions are studied.

What are the common drug interactions of Tekturna and Klonopin, by gender? *:
female:
- Malaise (a feeling of general discomfort or uneasiness)
- Abdominal discomfort
- Adverse event
- Angioedema (rapid swelling of the dermis)
- Apathy
- Blood pressure decreased
- Blood sodium decreased
- Chest pain
- Chronic kidney disease
- Creatinine renal clearance decreased
male:
- Asthenia (weakness)
- Headache (pain in head)
- Photophobia (extreme sensitivity to light)
- Sinus bradycardia (an unusually slow heartbeat due to heart disease)
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Urinary incontinence (inability to control the flow of urine and involuntary urination)
- Aortic disorder
- Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
- Blood pressure systolic increased
- Depression
What are the common drug interactions of Tekturna and Klonopin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Asthenia (weakness)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Diastolic dysfunction
- Dizziness
- Dysarthria (speech disorder)
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Hypokalaemia (low potassium)
- Hypotension (abnormally low blood pressure)
- Loss of consciousness
40-49:
n/a
50-59:
- Renal failure (kidney dysfunction)
- Angioedema (rapid swelling of the dermis)
- Chest pain
- Chronic kidney disease
- Depression
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Dyspnoea (difficult or laboured respiration)
- Fatigue (feeling of tiredness)
- Fluid retention (an abnormal accumulation of fluid in the blood)
- Lip swelling
60+:
- Malaise (a feeling of general discomfort or uneasiness)
- Abdominal discomfort
- Headache (pain in head)
- Hepatic enzyme increased
- Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
- Inappropriate antidiuretic hormone secretion
- Intervertebral disc protrusion (spinal disc protrusion)
- Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
- Nausea (feeling of having an urge to vomit)
- Poor quality sleep
What are the existing conditions these people have? *
- Pain: 4 people, 18.18%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 18.18%
- Malignant Hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage): 3 people, 13.64%
- High Blood Cholesterol: 3 people, 13.64%
- Wheezing (a high-pitched whistling sound made while you breath): 2 people, 9.09%
- Sleep Disorder: 2 people, 9.09%
- Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 2 people, 9.09%
- Blood Pressure Abnormal: 2 people, 9.09%
- Asthma: 2 people, 9.09%
* Approximation only. Some reports may have incomplete information.
Do you take Tekturna and Klonopin?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Tekturna and Klonopin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tekturna:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Klonopin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tekturna and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Klonopin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on aliskiren hemifumarate and clonazepam (the active ingredients of Tekturna and Klonopin, respectively), and Tekturna and Klonopin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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