Temodar and Klonopin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temodar (temozolomide) and Klonopin (clonazepam). Common drug interactions include seizure among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Temodar and Klonopin. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Klonopin?

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 65,112 Klonopin users. Check the latest studies of Klonopin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

19 people who take Temodar and Klonopin together, and have interactions are studied.

What are the common drug interactions of Temodar and Klonopin, by gender? *:

female:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cerebral haemorrhage (bleeding within the brain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Sepsis (a severe blood infection that can lead to organ failure and death)
Bone marrow failure
Cardiac arrest
Death
Diarrhoea
Disease progression

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Haemorrhage intracranial (bleeding within the skull)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Pain in extremity
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Constipation

What are the common drug interactions of Temodar and Klonopin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dysarthria (speech disorder)
Fall
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

n/a

40-49:

Diarrhoea
Feeding disorder (when children refuse to eat certain food groups)
Nausea (feeling of having an urge to vomit)

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Cerebral haemorrhage (bleeding within the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Coma (state of unconsciousness lasting more than six hours)
Craniotomy
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Haemorrhage intracranial (bleeding within the skull)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

Cerebral haemorrhage (bleeding within the brain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Ventricular extrasystoles (premature cardiac contraction)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Bradycardia (abnormally slow heart action)
Cardiac arrest
Fluid retention (an abnormal accumulation of fluid in the blood)
Lethargy (tiredness)

What are the existing conditions these people have? *

Pain: 3 people, 15.79%
Simple Partial Seizures (seizures which affect only a small region of the brain): 1 person, 5.26%
Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 5.26%
Leukaemia (blood or bone marrow cancer): 1 person, 5.26%
Infection: 1 person, 5.26%
Hypotension (abnormally low blood pressure): 1 person, 5.26%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.26%
Breast Cancer: 1 person, 5.26%
Brain Neoplasm Malignant (brain cancer tumour): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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