Temodar and Thalidomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temodar (temozolomide) and Thalidomide (thalidomide). Common drug interactions include thrombocytopenia among females and gastrooesophageal reflux disease among males.

The phase IV clinical study analyzes what interactions people have when they take Temodar and Thalidomide. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Thalidomide?

Thalidomide has active ingredients of thalidomide. eHealthMe is studying from 16,473 Thalidomide users. Check the latest studies of Thalidomide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

53 people who take Temodar and Thalidomide together, and have interactions are studied.

Temodar and Thalidomide drug interactions.

What are the common drug interactions of Temodar and Thalidomide, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Blood lactate dehydrogenase increased
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoaesthesia (reduced sense of touch or sensation)
Oedema peripheral (superficial swelling)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

male:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Dyspnoea (difficult or laboured respiration)
Thrombocytopenia (decrease of platelets in blood)
Chest pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Neck pain
Pain
Pyrexia (fever)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the common drug interactions of Temodar and Thalidomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Carcinoma in situ (early form of cancer)
Neoplasm malignant (cancer tumour)
Premature menopause
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

40-49:

Constipation
Neutropenia (an abnormally low number of neutrophils)
Acute pre-renal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Affect lability (emotional incontinence)
Anal pruritus (anal itching)
Anuria (failure of the kidneys to produce urine)
Colitis (inflammation of colon)
Colitis pseudomembranous (antibiotic-associated diarrhoea)
Culture stool positive
Death

50-59:

Depressed level of consciousness
Depression
Fatigue (feeling of tiredness)
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemoglobin decreased
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Malignant neoplasm progression (cancer tumour came back)

60+:

Oedema peripheral (superficial swelling)
Blood lactate dehydrogenase increased
Back pain
Blood creatinine increased
Bone disorder
Bone fissure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cellulitis (infection under the skin)
Cerebral infarction (less blood supply to brain resulting tissue damage)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 5 people, 9.43%
Headache (pain in head): 5 people, 9.43%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 3 people, 5.66%
Choroid Plexus Carcinoma (cancer of nerve complex in brain): 3 people, 5.66%
Brain Neoplasm Malignant (brain cancer tumour): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

Do you take Temodar and Thalidomide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously