Temodar and Trileptal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temodar (temozolomide) and Trileptal (oxcarbazepine). Common drug interactions include chills among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Temodar and Trileptal. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

On Jul, 19, 2026

20 people who take Temodar and Trileptal together, and have interactions are studied.

Temodar and Trileptal drug interactions.

What are the common drug interactions of Temodar and Trileptal, by gender? *:

female:

Chills (felling of cold)
Hyperglycaemia (high blood sugar)
Influenza like illness
Nausea (feeling of having an urge to vomit)
Vomiting
Asthenia (weakness)
Bone marrow failure
Dehydration (dryness resulting from the removal of water)
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)

male:

Cough
Pyrexia (fever)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Pain
Petechiae (a small red or purple spot caused by bleeding into the skin)
Platelet count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Upper respiratory tract infection
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Temodar and Trileptal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cerebral haemorrhage (bleeding within the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Gait disturbance
Nodule (a growth of abnormal tissue)
Pneumomediastinum (air is present in the mediastinum)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

30-39:

Drug hypersensitivity
Erythema multiforme (a type of hypersensitivity reaction)
Brain neoplasm malignant (brain cancer tumour)
Cellulitis (infection under the skin)
Pneumonia
Pruritus (severe itching of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion

40-49:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Cough
Ear pain
Headache (pain in head)
Herpetic stomatitis (inflammation of the mouth caused by herpes simplex virus)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Pain
Petechiae (a small red or purple spot caused by bleeding into the skin)

50-59:

Asthenia (weakness)
Bone marrow failure
Dehydration (dryness resulting from the removal of water)
Febrile neutropenia (fever with reduced white blood cells)
Hyperglycaemia (high blood sugar)
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Impaired work ability
Septic shock (shock due to blood infection)
Blood creatinine increased

60+:

Blood potassium increased
Blood sodium decreased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Confusional state
Hyperglycaemia (high blood sugar)
Infection

What are the existing conditions these people have? *

Brain Neoplasm Malignant (brain cancer tumour): 4 people, 20.00%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 2 people, 10.00%
Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 1 person, 5.00%
Oedema (fluid collection in tissue): 1 person, 5.00%
Neoplasm Malignant (cancer tumour): 1 person, 5.00%
Malignant Neoplasm Of Pleura (cancer tumour of lung covering): 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.00%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 1 person, 5.00%
Asthma: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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