Temodar and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temodar (temozolomide) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include anxiety among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Temodar and Vicodin. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 08, 2026

50 people who take Temodar and Vicodin together, and have interactions are studied.

What are the common drug interactions of Temodar and Vicodin, by gender? *:

female:

Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Atelectasis (partial or complete collapse of the lung)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood creatinine increased
Bone disorder
Bone fissure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cellulitis (infection under the skin)

male:

Fall
Fatigue (feeling of tiredness)
Renal failure acute (rapid kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)
Chills (felling of cold)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Depressed level of consciousness
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the common drug interactions of Temodar and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Aspartate aminotransferase increased
Candidiasis (candidiasis or thrush is a fungal infection)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dehydration (dryness resulting from the removal of water)
Disease progression
Failure to thrive (inadequate weight gain and physical growth in children)
Fatigue (feeling of tiredness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Metastases to central nervous system (cancer spreads to central nervous system)

30-39:

Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)

40-49:

Fall
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Hepatic enzyme increased
Hepatic steatosis (fatty liver disease)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Urinary tract infection

50-59:

Abdominal pain upper
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bacteraemia (presence of bacteria in the blood)
Balance disorder
Biliary neoplasm (biliary tumour)
Blood alkaline phosphatase increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Clostridial infection (infectious conditions by clostridium bacteria)
Decreased activity

60+:

Fall
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Bone disorder
Bone fissure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 6 people, 12.00%
Nausea (feeling of having an urge to vomit): 4 people, 8.00%
Depression: 4 people, 8.00%
Stress And Anxiety: 3 people, 6.00%
Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 3 people, 6.00%
Brain Neoplasm Malignant (brain cancer tumour): 3 people, 6.00%
Brain Neoplasm (tumour of brain): 3 people, 6.00%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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