Temozolomide and Dactinomycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temozolomide (temozolomide) and Dactinomycin (dactinomycin). Common drug interactions include ascites among females and tubulointerstitial nephritis among males.

The phase IV clinical study analyzes what interactions people have when they take Temozolomide and Dactinomycin. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Temozolomide?

Temozolomide has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 16,644 Temozolomide users. Check the latest studies of Temozolomide.

What is Dactinomycin?

Dactinomycin has active ingredients of dactinomycin. eHealthMe is studying from 2,577 Dactinomycin users. Check the latest studies of Dactinomycin.

On Jul, 13, 2026

77 people who take Temozolomide and Dactinomycin together, and have interactions are studied.

Temozolomide and Dactinomycin drug interactions.

What are the common drug interactions of Temozolomide and Dactinomycin, by gender? *:

female:

Ascites (accumulation of fluid in the abdominal cavity)
Drug ineffective
Metastases to lymph nodes (cancer spreads to lymph node)
Malignant neoplasm progression (cancer tumour came back)
Desmoplastic small round cell tumour (soft tissue cancer)
Metastases to liver (cancer spreads to liver)
Metastases to peritoneum (cancer spreads to peritoneum)
Disease progression
Vomiting
Neutropenia (an abnormally low number of neutrophils)

male:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Ewing's sarcoma recurrent (malignant small, round, blue cell tumour- recurrent)
Nausea (feeling of having an urge to vomit)
Osteonecrosis (death of bone)
Vomiting
Alopecia (absence of hair from areas of the body)
Bone marrow failure
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug ineffective

What are the common drug interactions of Temozolomide and Dactinomycin, by age (0-1 to 60+)? *:

0-1:

Nausea (feeling of having an urge to vomit)
Vomiting
Neutropenia (an abnormally low number of neutrophils)
Renal disorder (kidney disease)
Alopecia (absence of hair from areas of the body)
Disease progression
Haemorrhage intracranial (bleeding within the skull)
Therapeutic response decreased (less preventive response)

2-9:

Enterocolitis infectious
Large intestine perforation (hole in large intestine)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Malignant neoplasm progression (cancer tumour came back)
Bone marrow failure
Disease progression
Mucosal inflammation (infection of mucous membrane)
Neoplasm progression (growth of tumour)
Radiation skin injury
Retinopathy (acute damage to the retina of the eye)

10-19:

Ascites (accumulation of fluid in the abdominal cavity)
Drug ineffective
Metastases to lymph nodes (cancer spreads to lymph node)
Malignant neoplasm progression (cancer tumour came back)
Desmoplastic small round cell tumour (soft tissue cancer)
Metastases to liver (cancer spreads to liver)
Metastases to peritoneum (cancer spreads to peritoneum)
Disease progression
Neoplasm progression (growth of tumour)
Febrile neutropenia (fever with reduced white blood cells)

20-29:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Ewing's sarcoma recurrent (malignant small, round, blue cell tumour- recurrent)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Metastases to lung (cancer spreads to lung)
Osteonecrosis (death of bone)

30-39:

Osteonecrosis (death of bone)

40-49:

n/a

50-59:

n/a

60+:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)
Vomiting

What are the existing conditions these people have? *

Desmoplastic Small Round Cell Tumor: 28 people, 36.36%
Malignant Neoplasm Progression (cancer tumour came back): 19 people, 24.68%
Ewing's Sarcoma (malignant small, round, blue cell tumour): 16 people, 20.78%
Ewing's Sarcoma Metastatic (malignant small, round, blue cell tumour-metastatic): 8 people, 10.39%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

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