Tenex and Effexor xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tenex (guanfacine hydrochloride) and Effexor xr (venlafaxine hydrochloride). Common drug interactions include post-traumatic stress disorder among females and appetite increased among males.

The phase IV clinical study analyzes what interactions people have when they take Tenex and Effexor xr. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Tenex?

Tenex has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,865 Tenex users. Check the latest studies of Tenex.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

On Jul, 25, 2026

12 people who take Tenex and Effexor xr together, and have interactions are studied.

What are the common drug interactions of Tenex and Effexor Xr, by gender? *:

female:

Post-traumatic stress disorder
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Pain
Suicidal ideation
Nephrolithiasis (calculi in the kidneys)
Renal failure (kidney dysfunction)
Abdominal pain
Aggression
Agitation (state of anxiety or nervous excitement)
Anger

male:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Cough
Headache (pain in head)
Hypersensitivity
Infectious peritonitis (inflammation of the peritoneum, typically caused by bacterial infection)
Oropharyngeal pain
Pain
Peritoneal dialysis complication
Sedation
Thromboembolism (obstruction of artery by blood clot)

What are the common drug interactions of Tenex and Effexor Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Diarrhoea
Flatulence (flatus expelled through the anus)

10-19:

Abdominal pain
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Arthralgia (joint pain)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Irritability
Lipid metabolism disorder (genetic disorders are caused by errors in fatty acid metabolism)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

20-29:

n/a

30-39:

Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Post-traumatic stress disorder
Thromboembolism (obstruction of artery by blood clot)
Visual impairment

40-49:

Hypersensitivity
Infectious peritonitis (inflammation of the peritoneum, typically caused by bacterial infection)
Oropharyngeal pain
Pain
Peritoneal dialysis complication
Sedation
Cough
Decreased appetite
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)

50-59:

Pain
Rash pruritic (redness with itching)

60+:

n/a

What are the existing conditions these people have? *

Sleep Disorder: 5 people, 41.67%
Stress And Anxiety: 1 person, 8.33%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 8.33%
Insomnia (sleeplessness): 1 person, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Hepatitis C: 1 person, 8.33%
Birth Control: 1 person, 8.33%
Antithrombin Iii Deficiency (rare hereditary disorder that generally comes to light when a patient suffers recurrent venous thrombosis and pulmonary embolism, and repetitive intrauterine fetal death (iufd)): 1 person, 8.33%
Affective Disorder (mental disorder): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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