Tenex and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tenex (guanfacine hydrochloride) and Pepcid (famotidine). Common drug interactions include pyrexia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tenex and Pepcid. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Tenex?

Tenex has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,865 Tenex users. Check the latest studies of Tenex.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 26, 2026

22 people who take Tenex and Pepcid together, and have interactions are studied.

What are the common drug interactions of Tenex and Pepcid, by gender? *:

female:

Pyrexia (fever)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Pain
Suicide attempt
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Adrenal disorder

male:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anaphylactic reaction (serious allergic reaction)
Bradycardia (abnormally slow heart action)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Insomnia (sleeplessness)
Nephrogenic anaemia (anaemia due to kidney disease)
Overweight
Respiratory failure (inadequate gas exchange by the respiratory system)
Renal failure (kidney dysfunction)

What are the common drug interactions of Tenex and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Injection site erythema (redness at injection site)
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Arthralgia (joint pain)
Chest pain
Depression

20-29:

n/a

30-39:

Adrenal disorder
Adverse reaction
Chills (felling of cold)
Confusional state
Cough
Depression
Drug ineffective
Feeling drunk
Headache (pain in head)
Hip fracture

40-49:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Renal failure (kidney dysfunction)
Hypertensive nephropathy (hypertensive renal disease)
Nephropathy (damage to or disease of a kidney)
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)
Bradycardia (abnormally slow heart action)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

50-59:

Eye haemorrhage (bleeding in the eye)
International normalised ratio increased

60+:

Dyspnoea (difficult or laboured respiration)
Cytomegalovirus infection
Haemoglobin decreased
Hallucination, visual (seeing things that aren't there)
Hypotension (abnormally low blood pressure)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Hypovolaemia (a decreased volume of circulating blood in the body)
Immunosuppression
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)

What are the existing conditions these people have? *

Pain: 11 people, 50.00%
Neuralgia (pain in one or more nerves): 8 people, 36.36%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 8 people, 36.36%
Fluid Retention (an abnormal accumulation of fluid in the blood): 8 people, 36.36%
Blood Pressure Abnormal: 6 people, 27.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.09%
Drowsiness: 2 people, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 9.09%
Adrenocortical Insufficiency Acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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