Tenex and Sertraline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tenex (guanfacine hydrochloride) and Sertraline (sertraline hydrochloride). Common drug interactions include visual impairment among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tenex and Sertraline. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Tenex?

Tenex has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,865 Tenex users. Check the latest studies of Tenex.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

On Jul, 14, 2026

15 people who take Tenex and Sertraline together, and have interactions are studied.

What are the common drug interactions of Tenex and Sertraline, by gender? *:

female:

Visual impairment
Atrophy (wasting away of a part of the body)
Burning sensation
Chronic kidney disease
Claustrophobia (fear of having no escape and being closed in small spaces)
Coeliac disease (simple food intolerance)
Constipation
Drug ineffective
Eye pain
Faecaloma (hard mass of fecal matter)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Cardiac arrest
Eye pain
Granulocytopenia (lack of granulocyte)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Headache (pain in head)
Nephrogenic anaemia (anaemia due to kidney disease)
Papilloedema (optic disc swelling)

What are the common drug interactions of Tenex and Sertraline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Eye pain
Headache (pain in head)
Papilloedema (optic disc swelling)
Therapeutic response unexpected
Visual impairment

10-19:

Aggression
Drug ineffective
Gait disturbance
Irritability
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Tearfulness (excess tearing)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Abnormal behaviour
Coeliac disease (simple food intolerance)

20-29:

Gynaecomastia (enlargement of the gland tissue of the male breast)

30-39:

n/a

40-49:

Atrophy (wasting away of a part of the body)
Burning sensation
Claustrophobia (fear of having no escape and being closed in small spaces)
Constipation
Drug ineffective
Eye pain
Faecaloma (hard mass of fecal matter)
Fall
Feeling hot
Gait disturbance

50-59:

Cardiac arrest
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

60+:

Chronic kidney disease

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 33.33%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 20.00%
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts): 3 people, 20.00%
Body Height Below Normal: 2 people, 13.33%
Head Circumference Abnormal: 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%
Indigestion: 2 people, 13.33%
Diabetes: 2 people, 13.33%
Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 2 people, 13.33%
Blood Phosphorus Decreased: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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