Thalidomide and Pamelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Thalidomide (thalidomide) and Pamelor (nortriptyline hydrochloride). Common drug interactions include impaired healing among females and abscess oral among males.

The phase IV clinical study analyzes what interactions people have when they take Thalidomide and Pamelor. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Thalidomide?

Thalidomide has active ingredients of thalidomide. eHealthMe is studying from 16,473 Thalidomide users. Check the latest studies of Thalidomide.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.



On Jul, 08, 2026

24 people who take Thalidomide and Pamelor together, and have interactions are studied.

Thalidomide and Pamelor drug interactions.

What are the common drug interactions of Thalidomide and Pamelor, by gender? *:

female:

  1. Impaired healing
  2. Osteitis (a general term for inflammation of bone)
  3. Osteomyelitis (infection of bone)
  4. Pain in jaw
  5. Diarrhoea
  6. Arteriovenous fistula
  7. Back pain
  8. Dehydration (dryness resulting from the removal of water)
  9. Fall
  10. Hypocalcaemia (levels of calcium in blood serum are abnormally low)

male:

  1. Abscess oral (abscess in the mouth)
  2. Anaemia macrocytic (a macrocytic class of anaemia)
  3. Blood creatinine increased
  4. Blood parathyroid hormone increased
  5. Blood phosphorus increased
  6. Body dysmorphic disorder (type of mental illness)
  7. Bone abscess
  8. Bone disorder
  9. Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Thalidomide and Pamelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abscess oral (abscess in the mouth)
  2. Anaemia macrocytic (a macrocytic class of anaemia)
  3. Anxiety
  4. Aortic dilatation
  5. Arteriovenous fistula
  6. Arthralgia (joint pain)
  7. Back disorder
  8. Back pain
  9. Blood albumin decreased
  10. Blood bicarbonate decreased

30-39:

n/a

40-49:

n/a

50-59:

  1. Constipation
  2. Diarrhoea
  3. Dysgeusia (disorder of the sense of taste)
  4. Dyspepsia (indigestion)
  5. Erythema (redness of the skin)
  6. Fatigue (feeling of tiredness)
  7. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Impaired healing
  10. Inflammation

60+:

  1. Arteriovenous fistula
  2. Back pain
  3. Osteopenia (a condition where bone mineral density is lower than normal)
  4. Osteoporosis (bones weak and more likely to break)
  5. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  6. Proteinuria (presence of protein in the urine)
  7. Renal failure (kidney dysfunction)
  8. Abscess oral (abscess in the mouth)
  9. Arthralgia (joint pain)
  10. Back disorder

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 22 people, 91.67%
  2. Pain: 20 people, 83.33%
  3. Limb Discomfort (discomfort in leg): 20 people, 83.33%
  4. Acute Kidney Failure: 9 people, 37.50%
  5. Stress And Anxiety: 3 people, 12.50%
  6. High Blood Pressure: 3 people, 12.50%
  7. Depression: 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Thalidomide and Pamelor?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Thalidomide and Pamelor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Thalidomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pamelor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Thalidomide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pamelor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on thalidomide and nortriptyline hydrochloride (the active ingredients of Thalidomide and Pamelor, respectively), and Thalidomide and Pamelor (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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