Theophylline and Codeine sulfate drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Theophylline (theophylline) and Codeine sulfate (codeine sulfate). Common drug interactions include loss of consciousness among females and cardio-respiratory arrest among males.
The phase IV clinical study analyzes what interactions people have when they take Theophylline and Codeine sulfate. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.
What is Theophylline?
Theophylline has active ingredients of theophylline. It is often used in asthma. eHealthMe is studying from 19,150 Theophylline users. Check the latest studies of Theophylline.
What is Codeine sulfate?
Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.
21 people who take Theophylline and Codeine sulfate together, and have interactions are studied.

What are the common drug interactions of Theophylline and Codeine Sulfate, by gender? *:
female:
- Loss of consciousness
- Lung neoplasm (tumour of lung)
- Menstruation irregular
- Nausea (feeling of having an urge to vomit)
- Oedema peripheral (superficial swelling)
- Pallor
- Palpitations (feelings or sensations that your heart is pounding or racing)
- Platelet count increased
- Respiratory tract infection
- Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
male:
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Oral candidiasis (fungal infection of mouth)
- Anxiety
- Arthralgia (joint pain)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Asthenia (weakness)
- Blood amylase increased
- Blood creatinine increased
- Blood glucose increased
- Blood potassium decreased
What are the common drug interactions of Theophylline and Codeine Sulfate, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- International normalised ratio decreased
- Lipase increased
- Loss of consciousness
- Lung neoplasm (tumour of lung)
- Menstruation irregular
- Nausea (feeling of having an urge to vomit)
- Oedema peripheral (superficial swelling)
- Pallor
- Palpitations (feelings or sensations that your heart is pounding or racing)
- Platelet count increased
30-39:
n/a
40-49:
- Abdominal distension
- Abdominal pain
- Anaemia (lack of blood)
- Anxiety
- Arthralgia (joint pain)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Blood amylase increased
- Blood creatinine increased
- Blood glucose increased
- Blood potassium decreased
50-59:
- Drug hypersensitivity
- Chest pain
- Haematochezia (passage of stools containing blood)
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
- Neck pain
- Road traffic accident
60+:
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Oral candidiasis (fungal infection of mouth)
- Hyperventilation
- Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
- Inappropriate antidiuretic hormone secretion
- Influenza
- Infusion site erythema (reddening of the skin at infusion site)
- Infusion site swelling
- Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
- Oedema peripheral (superficial swelling)
What are the existing conditions these people have? *
- Lung Cancer - Non-Small Cell (lung cancer): 5 people, 23.81%
- Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 5 people, 23.81%
- Hypersensitivity: 4 people, 19.05%
- High Blood Pressure: 4 people, 19.05%
- Dyspnea (difficult or laboured breathing): 4 people, 19.05%
- Diabetes: 4 people, 19.05%
- Cough: 4 people, 19.05%
- Inappropriate Antidiuretic Hormone Secretion: 2 people, 9.52%
- Immunodeficiency: 2 people, 9.52%
- Cardiac Disorder: 2 people, 9.52%
* Approximation only. Some reports may have incomplete information.
Do you take Theophylline and Codeine sulfate?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Theophylline (19,150 reports)
- Codeine sulfate (4,510 reports)
Browse all drug interactions of Theophylline and Codeine sulfate:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Theophylline:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Codeine sulfate:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Theophylline and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Codeine sulfate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
- Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
- Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
- Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on theophylline and codeine sulfate (the active ingredients of Theophylline and Codeine sulfate, respectively), and Theophylline and Codeine sulfate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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