Thorazine and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Thorazine (chlorpromazine hydrochloride) and Pepcid (famotidine). Common drug interactions include fall among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Thorazine and Pepcid. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Thorazine?

Thorazine has active ingredients of chlorpromazine hydrochloride. It is often used in bipolar disorder. eHealthMe is studying from 3,237 Thorazine users. Check the latest studies of Thorazine.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Aug, 03, 2026

47 people who take Thorazine and Pepcid together, and have interactions are studied.

What are the common drug interactions of Thorazine and Pepcid, by gender? *:

female:

Fall
Renal failure (kidney dysfunction)
Vomiting
Diabetic coma
Pancreatitis (inflammation of pancreas)
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Asthenia (weakness)

male:

Pruritus (severe itching of the skin)
Depression
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Injury
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)

What are the common drug interactions of Thorazine and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Depression
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Tardive dyskinesia (a disorder that involves involuntary movements)
Angiopathy (generic term for a disease of the blood vessels)
Blood cholesterol increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Intermittent explosive disorder (behavioural disorder characterized by extreme expressions of anger)
Lung disorder (lung disease)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Blood cholesterol increased
Diabetes mellitus inadequate control
Neuropathy peripheral (surface nerve damage)
Obesity (having too much body fat)
Blood triglycerides increased
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

50-59:

Anaemia (lack of blood)
Blood cholesterol increased
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Glycosuria (excretion of glucose into the urine)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperglycaemia (high blood sugar)
Mucosal inflammation (infection of mucous membrane)

60+:

Foot fracture
Anxiety
Depression
Dizziness
Gait disturbance
Haemoglobin decreased
Headache (pain in head)
Hypertension (high blood pressure)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

What are the existing conditions these people have? *

Pain: 7 people, 14.89%
Stress And Anxiety: 6 people, 12.77%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 10.64%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 4 people, 8.51%
Depression: 4 people, 8.51%
Migraine (headache): 3 people, 6.38%
Memory Loss: 3 people, 6.38%
Insomnia (sleeplessness): 3 people, 6.38%
High Blood Pressure: 3 people, 6.38%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Thorazine and Pepcid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously