Tiazac and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tiazac (diltiazem hydrochloride) and Prolia (denosumab). Common drug interactions include gastric disorder among females and joint swelling among males.

The phase IV clinical study analyzes what interactions people have when they take Tiazac and Prolia. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Tiazac?

Tiazac has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 4,761 Tiazac users. Check the latest studies of Tiazac.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

On Jul, 26, 2026

38 people who take Tiazac and Prolia together, and have interactions are studied.

What are the common drug interactions of Tiazac and Prolia, by gender? *:

female:

Gastric disorder (disease of stomach)
Gingival disorder (gum disease)
Hepatitis (inflammation of the liver)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Inflammation
Pain
Abdominal pain
Fatigue (feeling of tiredness)
Headache (pain in head)

male:

Joint swelling
Bladder cancer
Nausea (feeling of having an urge to vomit)
Rib fracture
Transitional cell carcinoma (cancer tumour inner most layer of urinary system)
Upper limb fracture
Blood potassium decreased
Bradycardia (abnormally slow heart action)
Dehydration (dryness resulting from the removal of water)
Haematoma (collection of blood outside the blood vessels)

What are the common drug interactions of Tiazac and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Feeling hot
Headache (pain in head)
Hot flush (sudden feelings of heat)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pain in extremity
Pain of skin
Palpitations (feelings or sensations that your heart is pounding or racing)
Peripheral swelling

60+:

Abdominal pain
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Cataract (clouding of the lens inside the eye)
Chest discomfort
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cough
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypotension (abnormally low blood pressure)
Localised oedema (fluid retention in a particular part of the body)

What are the existing conditions these people have? *

Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 16 people, 42.11%
Sleep Disorder: 3 people, 7.89%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 7.89%
Pain: 3 people, 7.89%
Nausea (feeling of having an urge to vomit): 3 people, 7.89%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 3 people, 7.89%
Blood Iron Decreased: 3 people, 7.89%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 7.89%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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