Tigan and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tigan (trimethobenzamide hydrochloride) and Savella (milnacipran hydrochloride). Common drug interactions include suicidal ideation among females.

The phase IV clinical study analyzes what interactions people have when they take Tigan and Savella. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Tigan?

Tigan has active ingredients of trimethobenzamide hydrochloride. It is often used in nausea. eHealthMe is studying from 1,904 Tigan users. Check the latest studies of Tigan.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

On Jul, 11, 2026

20 people who take Tigan and Savella together, and have interactions are studied.

What are the common drug interactions of Tigan and Savella, by gender? *:

female:

Suicidal ideation
Fatigue (feeling of tiredness)
Drug ineffective
Confusional state
Dyspnoea (difficult or laboured respiration)
Emotional disorder
Fall
Fungal infection
Insomnia (sleeplessness)
Neck pain

male:

n/a

What are the common drug interactions of Tigan and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Sleep attacks
Suicidal ideation
Victim of abuse
Bedridden
Anxiety
Drug ineffective
Memory impairment

30-39:

n/a

40-49:

Abdominal pain upper
Diarrhoea
Injection site bruising
Injection site pain

50-59:

Drug ineffective
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Pulmonary arterial pressure increased

60+:

Abdominal mass (localized enlargement or swelling in the human abdomen)
Affect lability (emotional incontinence)
Burning sensation
Butterfly rash
Cataract (clouding of the lens inside the eye)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chorea (abnormal involuntary movement disorder)
Colonic polyp (extra part of colon tissue grow in intestine)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 65.00%
Drowsiness: 2 people, 10.00%
Depression: 2 people, 10.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 10.00%
Tardive Dyskinesia (a disorder that involves involuntary movements): 1 person, 5.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.00%
Impaired Gastric Emptying: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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