Tikosyn and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tikosyn (dofetilide) and Compazine (prochlorperazine maleate). Common drug interactions include pain among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Tikosyn and Compazine. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Jul, 06, 2026

13 people who take Tikosyn and Compazine together, and have interactions are studied.

Tikosyn and Compazine drug interactions.

What are the common drug interactions of Tikosyn and Compazine, by gender? *:

female:

Pain
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Blood creatinine decreased
Blood pressure decreased
Cardiac arrest
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt prolonged

male:

Cardiac arrest
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Chest discomfort
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Tikosyn and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Blood creatinine decreased
Blood pressure decreased
Cystitis (inflammation of the wall of the bladder)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Interstitial lung disease
Renal failure (kidney dysfunction)

60+:

Cardiac arrest
Hypotension (abnormally low blood pressure)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt prolonged
Hypoperfusion (decreased blood flow through an organ)
Kidney infection
Nephrolithiasis (calculi in the kidneys)
Oral candidiasis (fungal infection of mouth)
Pericardial effusion (fluid around the heart)
Pulseless electrical activity

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 7 people, 53.85%
Hypersensitivity: 6 people, 46.15%
Pain: 6 people, 46.15%
Multiple Myeloma (cancer of the plasma cells): 6 people, 46.15%
Stress And Anxiety: 4 people, 30.77%
Diabetes: 3 people, 23.08%
Liposarcoma (a cancer tumour that arises in fat cells in deep soft tissue): 2 people, 15.38%
Blood Glucose Decreased: 1 person, 7.69%
Constipation: 1 person, 7.69%
Cough: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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