Tikosyn and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tikosyn (dofetilide) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include eye disorder among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Tikosyn and Fluoxetine. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,823 Fluoxetine users. Check the latest studies of Fluoxetine.

On Jul, 23, 2026

46 people who take Tikosyn and Fluoxetine together, and have interactions are studied.

Tikosyn and Fluoxetine drug interactions.

What are the common drug interactions of Tikosyn and Fluoxetine, by gender? *:

female:

Eye disorder
Fatigue (feeling of tiredness)
Haematocrit decreased
Haemoglobin decreased
Heart rate increased
Hip fracture
Hypersensitivity
Hypotension (abnormally low blood pressure)
Impaired healing
Incontinence (lack of moderation or self-control)

male:

Dizziness
Drug ineffective
Asthenia (weakness)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic obstructive airways disease
Coma (state of unconsciousness lasting more than six hours)
Drug effect decreased
Ejection fraction decreased (systolic heart failure)
Electrocardiogram qt prolonged
Electrocardiogram t wave inversion

What are the common drug interactions of Tikosyn and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal distension
Cardiac disorder
Constipation
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Heart rate increased

50-59:

Dizziness
Fatigue (feeling of tiredness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Overdose
Vomiting

60+:

Asthenia (weakness)
Balance disorder
Anaemia (lack of blood)
Cardiomegaly (increased size of heart than normal)
Drug ineffective
Haemorrhage (bleeding)
Hypotension (abnormally low blood pressure)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Aphonia (inability to produce voice)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 10.87%
Cardiac Disorder: 5 people, 10.87%
Pain: 4 people, 8.70%
Blood Pressure Abnormal: 4 people, 8.70%
Ill-Defined Disorder: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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