Tikosyn and Ondansetron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tikosyn (dofetilide) and Ondansetron (ondansetron). Common drug interactions include cystitis among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Tikosyn and Ondansetron. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

What is Ondansetron?

Ondansetron has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 122,739 Ondansetron users. Check the latest studies of Ondansetron.

On Aug, 01, 2026

46 people who take Tikosyn and Ondansetron together, and have interactions are studied.

Tikosyn and Ondansetron drug interactions.

What are the common drug interactions of Tikosyn and Ondansetron, by gender? *:

female:

Cystitis (inflammation of the wall of the bladder)
Dysstasia (difficulty in standing)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gout (uric acid crystals building up in the body)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Kidney infection
Lactic acidosis (low ph in body tissues)

male:

Cardiac failure congestive
Bladder dysfunction
Fatigue (feeling of tiredness)
Infusion related reaction
Diarrhoea
Anaemia (lack of blood)
Back pain
Constipation
Febrile neutropenia (fever with reduced white blood cells)
Leukopenia (less number of white blood cells in blood)

What are the common drug interactions of Tikosyn and Ondansetron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Gout (uric acid crystals building up in the body)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Cardiac failure congestive
Bladder dysfunction
Back pain
Platelet count decreased
Blood calcium decreased
Decreased appetite
Fall
Infusion related reaction
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract infection

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 20 people, 43.48%
Pain: 12 people, 26.09%
Hypersensitivity: 8 people, 17.39%
Stress And Anxiety: 7 people, 15.22%
Nausea And Vomiting: 7 people, 15.22%
High Blood Pressure: 6 people, 13.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.04%
Cardiac Disorder: 6 people, 13.04%
Arrhythmias (irregular heartbeat): 5 people, 10.87%
High Blood Cholesterol: 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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