Tobi and Heparin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tobi (tobramycin) and Heparin (heparin sodium). Common drug interactions include vitamin e decreased among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Tobi and Heparin. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Tobi?

Tobi has active ingredients of tobramycin. eHealthMe is studying from 10,011 Tobi users. Check the latest studies of Tobi.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

83 people who take Tobi and Heparin together, and have interactions are studied.

What are the common drug interactions of Tobi and Heparin, by gender? *:

female:

Vitamin e decreased
White blood cell count decreased
Cough
Pyrexia (fever)
Decreased appetite
Fatigue (feeling of tiredness)
Respiratory distress (difficulty in breathing)
Asthenia (weakness)
Cystic fibrosis lung (fibrosis with cyst in the lung)
Dehydration (dryness resulting from the removal of water)

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Dyspnoea (difficult or laboured respiration)
Blood urea increased
Urticaria (rash of round, red welts on the skin that itch intensely)
Chest discomfort
Pseudomonas test positive
Staphylococcus test positive
Chest pain
Pneumonia
Decreased appetite

What are the common drug interactions of Tobi and Heparin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Blood bilirubin decreased
Blood potassium decreased
Blood pressure decreased
Body temperature increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carbon dioxide decreased
Dyspnoea (difficult or laboured respiration)
Eosinophil count increased
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Drug level increased
Blood urea increased
Blood glucose increased
Bronchial wall thickening
Pneumonia
Blood chloride increased
Blood urea decreased
Forced expiratory volume decreased (decreased lung expired air volume)
Protein total decreased

20-29:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Non-cardiac chest pain
Cough
Cystic fibrosis (disease of the secretary glands)
Nausea (feeling of having an urge to vomit)
Pulmonary haemorrhage (acute bleeding from the lung)
Vomiting
Anterior chamber flare (flare in the anterior chamber)
Chest wall abscess

30-39:

Dyspnoea (difficult or laboured respiration)
Cough
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Asthenia (weakness)
Diarrhoea
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pyrexia (fever)
Chest pain
Productive cough
Sputum discoloured

40-49:

Fatigue (feeling of tiredness)
Glycosylated haemoglobin increased
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Lymphocyte count decreased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Protein total decreased
Sinusitis (inflammation of sinus)
Sputum discoloured

50-59:

Blood pressure decreased
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Productive cough
Respiratory distress (difficulty in breathing)
Abdominal distension
Acute respiratory failure
Anaemia (lack of blood)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Back pain

60+:

Ventricular pre-excitation
Blood creatinine increased
Blood urea increased
Drug level increased
Drug toxicity
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Oliguria (not enough urine)
Renal failure (kidney dysfunction)
Urinary sediment present

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 47 people, 56.63%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 42 people, 50.60%
Pain: 30 people, 36.14%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 27 people, 32.53%
Infective Pulmonary Exacerbation Of Cystic Fibrosis (severe infective lung disease with production of abnormally thick mucus): 23 people, 27.71%
Wheezing (a high-pitched whistling sound made while you breath): 20 people, 24.10%
Rickets (softening of bones): 19 people, 22.89%
Cough: 19 people, 22.89%
Nausea (feeling of having an urge to vomit): 18 people, 21.69%
Sleep Disorder: 15 people, 18.07%

* Approximation only. Some reports may have incomplete information.

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