Tofranil and Motrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tofranil (imipramine hydrochloride) and Motrin (ibuprofen). Common drug interactions include cardiac failure congestive among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Tofranil and Motrin. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

On Jul, 21, 2026

11 people who take Tofranil and Motrin together, and have interactions are studied.

What are the common drug interactions of Tofranil and Motrin, by gender? *:

female:

Cardiac failure congestive
Abdominal pain
Bacterial infection
Bladder discomfort
Burning sensation
Culture urine positive
Cystitis (inflammation of the wall of the bladder)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Micturition urgency (urgency to pass the urine)

male:

Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Atrioventricular block second degree (heart block second degree)
Blood glucose increased
Bradycardia (abnormally slow heart action)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Calcinosis (calcium deposits in any soft tissue)

What are the common drug interactions of Tofranil and Motrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Ovarian cyst (fluid filled sac of the ovary)
Vomiting

30-39:

n/a

40-49:

n/a

50-59:

Calcinosis (calcium deposits in any soft tissue)
Chest pain
Chest wall pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Fall
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)

60+:

Cardiac failure congestive
Abdominal distension
Bacterial infection
Bladder discomfort
Blood glucose increased
Bradycardia (abnormally slow heart action)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Burning sensation
Cardiac arrest
Cardiac valve disease (heart valve disease)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 9.09%
Urinary Tract Infection: 1 person, 9.09%
Uraemic Acidosis (acidosis caused by excess nitrogenous waste products in the urine): 1 person, 9.09%
Stress And Anxiety: 1 person, 9.09%
Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 9.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 9.09%
Micturition Urgency (urgency to pass the urine): 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Drowsiness: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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