Tolterodine and Clarithromycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tolterodine (tolterodine tartrate) and Clarithromycin (clarithromycin). Common drug interactions include local swelling among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Tolterodine and Clarithromycin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Tolterodine?

Tolterodine has active ingredients of tolterodine tartrate. It is often used in urge incontinence. eHealthMe is studying from 8,156 Tolterodine users. Check the latest studies of Tolterodine.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

74 people who take Tolterodine and Clarithromycin together, and have interactions are studied.

Tolterodine and Clarithromycin drug interactions.

What are the common drug interactions of Tolterodine and Clarithromycin, by gender? *:

female:

Local swelling (swelling at the site of some application of substance or injury)
Lower respiratory tract infection
Mobility decreased (ability to move is reduced)
Mood altered (changes in mood)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain in extremity
Psychological trauma
Rash
Renal failure (kidney dysfunction)

male:

Febrile neutropenia (fever with reduced white blood cells)
Lung infection
Blood phosphorus increased
Blood pressure fluctuation
Blood pressure increased
Cardiac failure
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Discomfort

What are the common drug interactions of Tolterodine and Clarithromycin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure fluctuation
Blood urea increased
Blood uric acid increased
Depression
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
Sluggishness (lacking alertness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased

50-59:

Death
Drug hypersensitivity
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

60+:

Dyspnoea (difficult or laboured respiration)
Haematemesis (vomiting of blood)
Vomiting
Hypersomnia (excessive daytime sleepiness (eds))
Mania (a state of abnormally elevated or irritable mood)
Pain
Psychotic disorder
Vision blurred
Weight decreased
Diplopia (double vision)

What are the existing conditions these people have? *

Lower Respiratory Tract Infection: 26 people, 35.14%
Stress And Anxiety: 24 people, 32.43%
Bladder Irritation: 23 people, 31.08%
Depression: 20 people, 27.03%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 15 people, 20.27%
Cardiac Failure: 11 people, 14.86%
High Blood Pressure: 9 people, 12.16%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.46%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 8.11%
Pain: 6 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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