Tolvaptan and Proair hfa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tolvaptan (tolvaptan) and Proair hfa (albuterol sulfate). Common drug interactions include headache among females and femur fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Tolvaptan and Proair hfa. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Tolvaptan?

Tolvaptan has active ingredients of tolvaptan. eHealthMe is studying from 5,685 Tolvaptan users. Check the latest studies of Tolvaptan.

What is Proair hfa?

Proair hfa has active ingredients of albuterol sulfate. It is often used in asthma. eHealthMe is studying from 53,227 Proair hfa users. Check the latest studies of Proair hfa.



On Jul, 03, 2026

15 people who take Tolvaptan and Proair hfa together, and have interactions are studied.

Tolvaptan and Proair hfa drug interactions.

What are the common drug interactions of Tolvaptan and Proair Hfa, by gender? *:

female:

  1. Headache (pain in head)
  2. Thirst
  3. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  4. Hypertension (high blood pressure)
  5. Nausea (feeling of having an urge to vomit)
  6. Polyuria (production of too much dilute urine)
  7. Surgery
  8. Vertigo
  9. Vomiting
  10. Chest discomfort

male:

  1. Femur fracture
  2. Joint swelling
  3. Neoplasm malignant (cancer tumour)
  4. Overweight
  5. Tremor (trembling or shaking movements in one or more parts of your body)
  6. Vitamin d decreased
  7. Fracture
  8. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  9. Hip fracture
  10. Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)

What are the common drug interactions of Tolvaptan and Proair Hfa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Headache (pain in head)
  2. Hypertension (high blood pressure)
  3. Nausea (feeling of having an urge to vomit)
  4. Polyuria (production of too much dilute urine)
  5. Surgery
  6. Thirst
  7. Vertigo
  8. Vomiting
  9. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  10. Infection

40-49:

  1. Arthralgia (joint pain)
  2. Blood sodium increased
  3. Dizziness
  4. Hyperkalaemia (damage to or disease of the kidney)
  5. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  6. Hypertension (high blood pressure)
  7. Overweight
  8. Tremor (trembling or shaking movements in one or more parts of your body)
  9. Vitamin d decreased

50-59:

  1. Constipation
  2. Depressed mood
  3. Dry mouth
  4. Insomnia (sleeplessness)
  5. Micturition disorder (disease of passing urine)
  6. Nocturia (the need to get up in the night to urinate)
  7. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  8. Poor quality sleep
  9. Sleep disorder
  10. Suicidal ideation

60+:

  1. Gastritis (inflammation of stomach)
  2. Hepatitis (inflammation of the liver)
  3. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  4. Oesophagitis (inflammation of oesophagus)
  5. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  6. Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

  1. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 4 people, 26.67%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 20.00%
  3. Blood Osmolarity Decreased: 3 people, 20.00%
  4. Nausea (feeling of having an urge to vomit): 1 person, 6.67%
  5. Hyperkalemia (damage to or disease of the kidney): 1 person, 6.67%
  6. High Blood Cholesterol: 1 person, 6.67%
  7. Depression: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tolvaptan and Proair hfa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tolvaptan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Proair hfa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tolvaptan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Proair hfa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tolvaptan and albuterol sulfate (the active ingredients of Tolvaptan and Proair hfa, respectively), and Tolvaptan and Proair hfa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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