Topicort and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topicort (desoximetasone) and Medrol (methylprednisolone). Common drug interactions include gastric ulcer among females and angina unstable among males.

The phase IV clinical study analyzes what interactions people have when they take Topicort and Medrol. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Topicort?

Topicort has active ingredients of desoximetasone. eHealthMe is studying from 3,423 Topicort users. Check the latest studies of Topicort.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

16 people who take Topicort and Medrol together, and have interactions are studied.

What are the common drug interactions of Topicort and Medrol, by gender? *:

female:

Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Heart rate irregular
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Ill-defined disorder
Injury
Lichenoid keratosis (a skin disorder described by rapid growing, reddish to brown, benign (noncancerous) lesion on the skin)

male:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Back pain
Eye pruritus (eye itching)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertension (high blood pressure)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Joint injury
Nausea (feeling of having an urge to vomit)
Neck injury

What are the common drug interactions of Topicort and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Back pain
Cardiac disorder
Chest pain
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anaphylactic reaction (serious allergic reaction)
Arteriosclerosis (thickening and hardening of arteries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cyst (a closed sac)
Dyspepsia (indigestion)

50-59:

Therapeutic response unexpected

60+:

Pruritus (severe itching of the skin)
Dysphagia (a condition in which swallowing is difficult or painful)
Influenza
Palpitations (feelings or sensations that your heart is pounding or racing)
Throat irritation
Vomiting
Abdominal discomfort
Abdominal pain
Adverse drug reaction
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Migraine (headache): 2 people, 12.50%
Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 2 people, 12.50%
Hypersensitivity: 2 people, 12.50%
Pain: 1 person, 6.25%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 6.25%
Itching: 1 person, 6.25%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 6.25%
Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 1 person, 6.25%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 6.25%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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