Topiramate and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topiramate (topiramate) and Actos (pioglitazone hydrochloride). Common drug interactions include weight decreased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Topiramate and Actos. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 11, 2026

58 people who take Topiramate and Actos together, and have interactions are studied.

What are the common drug interactions of Topiramate and Actos, by gender? *:

female:

Weight decreased
Acute respiratory failure
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Arthralgia (joint pain)
Bladder cancer
Blood calcium increased
Brain stem infarction (brainstem stroke)
Cardiac arrest
Cataract (clouding of the lens inside the eye)
Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood alkaline phosphatase increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic coma
Dyspepsia (indigestion)
Gamma-glutamyltransferase increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperglycaemia (high blood sugar)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the common drug interactions of Topiramate and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)
Pancreatitis (inflammation of pancreas)
Weight increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood chloride increased
Blood cholesterol increased
Blood gastrin increased
Blood triglycerides increased

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood glucose increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Drug ineffective
Hepatitis a
Malaise (a feeling of general discomfort or uneasiness)
Nerve injury
Pain
Renal injury (kidney injury)

50-59:

Chronic kidney disease
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Gamma-glutamyltransferase increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood cholesterol increased
Blood glucose increased

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Haemoglobin decreased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lung disorder (lung disease)
Micturition urgency (urgency to pass the urine)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Renal cyst (kidney cyst)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 22 people, 37.93%
Pain: 14 people, 24.14%
High Blood Pressure: 13 people, 22.41%
High Blood Cholesterol: 13 people, 22.41%
Type 2 Diabetes: 9 people, 15.52%
Stress And Anxiety: 9 people, 15.52%
Depression: 6 people, 10.34%
Cardiac Disorder: 6 people, 10.34%
Infection: 6 people, 10.34%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

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