Topiramate and Nuplazid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topiramate (topiramate) and Nuplazid (pimavanserin tartrate). Common drug interactions include pain in extremity among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Topiramate and Nuplazid. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

On Aug, 11, 2026

83 people who take Topiramate and Nuplazid together, and have interactions are studied.

Topiramate and Nuplazid drug interactions.

What are the common drug interactions of Topiramate and Nuplazid, by gender? *:

female:

Pain in extremity
Pharyngeal haemorrhage (pharyngeal bleeding)
Rash
Tardive dyskinesia (a disorder that involves involuntary movements)
Vision blurred
Weight decreased
Abdominal distension
Abnormal behaviour
Affect lability (emotional incontinence)
Back pain

male:

Hallucination (an experience involving the perception of something not present)
Inappropriate affect
Drug ineffective
Rash erythematous (redness of the skin)
Arthralgia (joint pain)
Communication disorder (speech and language disorder)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscular weakness (muscle weakness)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Peripheral swelling

What are the common drug interactions of Topiramate and Nuplazid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Delusion (a false belief or opinion)
Hallucination, auditory (perceiving sounds without auditory stimulus)

30-39:

n/a

40-49:

Eye swelling
Nonspecific reaction (unspecified reaction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected

50-59:

Drug ineffective
Abdominal distension
Fatigue (feeling of tiredness)
Memory impairment
Sluggishness (lacking alertness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chest pain

60+:

Hallucination (an experience involving the perception of something not present)
Hallucination, visual (seeing things that aren't there)
Tooth fracture
Hypersomnia (excessive daytime sleepiness (eds))
Therapeutic response unexpected
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Hospitalisation
Irritability
Urinary tract infection

What are the existing conditions these people have? *

Parkinson's Disease: 56 people, 67.47%
Hallucinations (sensations that appear real but are created by your mind): 44 people, 53.01%
Delusion (a false belief or opinion): 35 people, 42.17%
Psychotic Disorder Due To A General Medical Condition: 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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