Topotecan and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topotecan (topotecan hydrochloride) and Emla (lidocaine; prilocaine). Common drug interactions include diarrhoea among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Topotecan and Emla. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Jul, 09, 2026

18 people who take Topotecan and Emla together, and have interactions are studied.

What are the common drug interactions of Topotecan and Emla, by gender? *:

female:

Diarrhoea
Pyrexia (fever)
Orbital oedema (swelling of orbit)
Febrile neutropenia (fever with reduced white blood cells)
Ovarian cancer (cancer of ovary)
Syncope (loss of consciousness with an inability to maintain postural tone)
Alopecia (absence of hair from areas of the body)
Bone pain
Cancer pain
Chest pain

male:

Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)
Death
Fatigue (feeling of tiredness)
Oral pain

What are the common drug interactions of Topotecan and Emla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Parainfluenzae virus infection
Anaemia (lack of blood)
Cough
Diarrhoea
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Orbital oedema (swelling of orbit)
Febrile neutropenia (fever with reduced white blood cells)
Metapneumovirus infection (infection with human metapneumovirus)

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)
Fatigue (feeling of tiredness)
Oral pain

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Alopecia (absence of hair from areas of the body)
Bone pain
Cancer pain
Chest pain
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Pulmonary haemorrhage (acute bleeding from the lung)
Small cell lung cancer (small cell cancer tumour of lung)

60+:

Death

What are the existing conditions these people have? *

Sleep Disorder: 13 people, 72.22%
Neuroblastoma (a cancer that forms in your nerve tissue): 8 people, 44.44%
Neoplasm Recurrence (reoccurrence of tumour): 7 people, 38.89%
Neuroblastoma Recurrent (reoccurrence of a cancer that forms in your nerve tissue): 6 people, 33.33%
Recurrent Cancer (repeated cancer): 4 people, 22.22%
Stress And Anxiety: 3 people, 16.67%
Prostate Cancer: 2 people, 11.11%
Neoplasm Malignant (cancer tumour): 2 people, 11.11%
Lung Cancer - Small Cell (lung cancer): 1 person, 5.56%
Appetite Disorder (abnormal eating habits): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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