Topotecan and Hexalen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topotecan (topotecan hydrochloride) and Hexalen (altretamine). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Topotecan and Hexalen. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

What is Hexalen?

Hexalen has active ingredients of altretamine. eHealthMe is studying from 45 Hexalen users. Check the latest studies of Hexalen.

On Jul, 14, 2026

12 people who take Topotecan and Hexalen together, and have interactions are studied.

Topotecan and Hexalen drug interactions.

What are the common drug interactions of Topotecan and Hexalen, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Abdominal distension
Dyspnoea (difficult or laboured respiration)
Fall
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematuria (presence of blood in urine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hydronephrosis (water inside the kidney)

male:

n/a

What are the common drug interactions of Topotecan and Hexalen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Death
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fall
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glomerulonephritis membranous (nephritis with inflammation of the capillary loops in the renal glomeruli)

20-29:

n/a

30-39:

n/a

40-49:

Contusion (a type of hematoma of tissue in which capillaries)
Death
Depression
Disease progression
Dizziness
Erythema (redness of the skin)
Fall
Fatigue (feeling of tiredness)
Loss of consciousness
Metastases to lymph nodes (cancer spreads to lymph node)

50-59:

Abdominal distension
Acquired oesophageal web (structural abnormalities in the oesophagus)
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematuria (presence of blood in urine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hydronephrosis (water inside the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)
Injury
Lymphadenopathy (disease or enlargement of lymph nodes)

60+:

n/a

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 11 people, 91.67%
Nausea (feeling of having an urge to vomit): 10 people, 83.33%
Muscle Aches (muscle pain): 10 people, 83.33%
Insomnia (sleeplessness): 10 people, 83.33%
Herpes Virus Infection: 10 people, 83.33%
Osteoporosis (bones weak and more likely to break): 6 people, 50.00%
Breast Cancer: 4 people, 33.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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