Toprol-xl and Edecrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Toprol-xl (metoprolol succinate) and Edecrin (ethacrynic acid). Common drug interactions include pruritus among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Toprol-xl and Edecrin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Toprol-xl?

Toprol-xl has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 40,636 Toprol-xl users. Check the latest studies of Toprol-xl.

What is Edecrin?

Edecrin has active ingredients of ethacrynic acid. It is often used in fluid retention. eHealthMe is studying from 252 Edecrin users. Check the latest studies of Edecrin.

On Jul, 15, 2026

17 people who take Toprol-xl and Edecrin together, and have interactions are studied.

Toprol-xl and Edecrin drug interactions.

What are the common drug interactions of Toprol-Xl and Edecrin, by gender? *:

female:

Pruritus (severe itching of the skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Decreased appetite
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dyspnoea (difficult or laboured respiration)

male:

Flushing (the warm, red condition of human skin)

What are the common drug interactions of Toprol-Xl and Edecrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Pruritus (severe itching of the skin)
Fatigue (feeling of tiredness)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Decreased appetite
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 7 people, 41.18%
Platelet Count Increased: 5 people, 29.41%
High Blood Cholesterol: 2 people, 11.76%
Sleep Disorder: 1 person, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Nuclear Magnetic Resonance Imaging Abdominal: 1 person, 5.88%
Nervousness: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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