Toradol and Protamine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Toradol (ketorolac tromethamine) and Protamine sulfate (protamine sulfate). Common drug interactions include injury among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Toradol and Protamine sulfate. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Toradol?

Toradol has active ingredients of ketorolac tromethamine. It is often used in pain. eHealthMe is studying from 9,231 Toradol users. Check the latest studies of Toradol.

What is Protamine sulfate?

Protamine sulfate has active ingredients of protamine sulfate. eHealthMe is studying from 3,292 Protamine sulfate users. Check the latest studies of Protamine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

26 people who take Toradol and Protamine sulfate together, and have interactions are studied.

Toradol and Protamine sulfate drug interactions.

What are the common drug interactions of Toradol and Protamine Sulfate, by gender? *:

female:

Injury
Anxiety
Renal failure (kidney dysfunction)
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Fear
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Depression
Renal injury (kidney injury)
Stress

male:

Anxiety
Fear
Death
Depression
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cerebral haemorrhage (bleeding within the brain)
Adverse event
Anaphylactic reaction (serious allergic reaction)
Cardiac disorder
Cardiac failure

What are the common drug interactions of Toradol and Protamine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Disability
Fear
Injury
Multi-organ failure (multisystem organ failure)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Adverse event
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Depression
Fear
Injury
Renal failure (kidney dysfunction)

60+:

Injury
Anxiety
Multi-organ failure (multisystem organ failure)
Death
Depression
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cerebral haemorrhage (bleeding within the brain)
Anaphylactic reaction (serious allergic reaction)
Cardiac disorder

What are the existing conditions these people have? *

Urinary Tract Infection: 2 people, 7.69%
Blood Pressure Abnormal: 2 people, 7.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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