Tracleer and Atacand drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tracleer (bosentan) and Atacand (candesartan cilexetil). Common drug interactions include diverticulum among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Tracleer and Atacand. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

What is Atacand?

Atacand has active ingredients of candesartan cilexetil. It is often used in high blood pressure. eHealthMe is studying from 22,473 Atacand users. Check the latest studies of Atacand.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

38 people who take Tracleer and Atacand together, and have interactions are studied.

What are the common drug interactions of Tracleer and Atacand, by gender? *:

female:

Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea exertional (breathlessness or shortness of breath)
Hepatic congestion (liver congestion)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
International normalised ratio increased
Lethargy (tiredness)
Loss of consciousness
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multi-organ failure (multisystem organ failure)

male:

Arrhythmia (irregular heartbeat)
Skin ulcer
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure congestive
Diarrhoea
Enterococcal infection
Hepatic steatosis (fatty liver disease)
Hepatomegaly (abnormal enlargement of the liver)
Pleural effusion (water on the lungs)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

What are the common drug interactions of Tracleer and Atacand, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

40-49:

Alanine aminotransferase increased
Arrhythmia (irregular heartbeat)
Aspartate aminotransferase increased
Brain death
Brain hypoxia (reduced supply of oxygen to the brain)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardioversion
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Coma (state of unconsciousness lasting more than six hours)

50-59:

Gastric disorder (disease of stomach)
Heart rate increased
Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Neuropathy peripheral (surface nerve damage)
Vitamin b12 deficiency

60+:

Dyspnoea (difficult or laboured respiration)
Blood alkaline phosphatase increased
Pneumonia
Alanine aminotransferase increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aspartate aminotransferase increased
Conjunctivitis (pink eye)
Diarrhoea
Emotional disorder
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 20 people, 52.63%
Systemic Sclerosis (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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