Tracleer and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tracleer (bosentan) and Soliris (eculizumab). Common drug interactions include haemoglobin decreased among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Tracleer and Soliris. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Jul, 09, 2026

12 people who take Tracleer and Soliris together, and have interactions are studied.

What are the common drug interactions of Tracleer and Soliris, by gender? *:

female:

Haemoglobin decreased
Fatigue (feeling of tiredness)
Asthenia (weakness)
Back pain
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Migraine (headache)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Dyspnoea (difficult or laboured respiration)
Gastric disorder (disease of stomach)
Haemoglobinuria (the presence of free haemoglobin in the urine)

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Viral infection
Femur fracture
Platelet count decreased
Pneumonia
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Heart valve replacement
Blood lactate dehydrogenase increased

What are the common drug interactions of Tracleer and Soliris, by age (0-1 to 60+)? *:

0-1:

Femur fracture
Platelet count decreased
Pneumonia
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary hypertension (increase in blood pressure in the lung artery)

2-9:

n/a

10-19:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Feeling hot
Haemoglobin decreased
Headache (pain in head)
Liver disorder (liver diseases)

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Gamma-glutamyltransferase increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Back pain
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Haemoglobin decreased
Haemoglobinuria (the presence of free haemoglobin in the urine)
Headache (pain in head)
Hepatic enzyme increased

60+:

Pneumonia
Haemoglobin decreased
Back pain
Blood glucose increased
Chest discomfort
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hot flush (sudden feelings of heat)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 6 people, 50.00%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 4 people, 33.33%
High Blood Pressure: 2 people, 16.67%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 1 person, 8.33%
Seasonal Allergy (allergic condition due to certain season): 1 person, 8.33%
Renal Impairment (severely reduced kidney function): 1 person, 8.33%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 8.33%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 1 person, 8.33%
Bone Pain: 1 person, 8.33%
Birth Control: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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