Tramadol and Aldactazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Aldactazide (hydrochlorothiazide; spironolactone). Common drug interactions include hyperkalaemia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Aldactazide. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

On Jul, 09, 2026

51 people who take Tramadol and Aldactazide together, and have interactions are studied.

Tramadol and Aldactazide drug interactions.

What are the common drug interactions of Tramadol and Aldactazide, by gender? *:

female:

Hyperkalaemia (damage to or disease of the kidney)
Hypertransaminasaemia
Hypophagia (reduced food intake)
Injection site pain
Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
Knee arthroplasty
Leukocytosis (increased white blood cells)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Malignant neoplasm progression (cancer tumour came back)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gout (uric acid crystals building up in the body)
Acute respiratory failure
Ankle fracture
Arthralgia (joint pain)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Atypical mycobacterium test positive

What are the common drug interactions of Tramadol and Aldactazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Acute myocardial infarction (acute heart attack)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Balance disorder
Fall
Hepatic enzyme increased
Hyperhidrosis (abnormally increased sweating)
Pain in extremity
Therapeutic response decreased (less preventive response)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood creatine phosphokinase increased
Gout (uric acid crystals building up in the body)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Myalgia (muscle pain)
Arthralgia (joint pain)
Hypokinesia (decreased bodily movement)
Joint stiffness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 37.25%
High Blood Cholesterol: 10 people, 19.61%
Renal Impairment (severely reduced kidney function): 6 people, 11.76%
Gastric Ulcer (stomach ulcer): 6 people, 11.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 9.80%
Headache (pain in head): 5 people, 9.80%
Gout (uric acid crystals building up in the body): 5 people, 9.80%
Back Pain: 5 people, 9.80%
Anaemia (lack of blood): 5 people, 9.80%
Renal Disorder (kidney disease): 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

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