Tramadol and Bupropion hydrobromide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Bupropion hydrobromide (bupropion hydrobromide). Common drug interactions include rhinitis allergic among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Bupropion hydrobromide. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Bupropion hydrobromide?

Bupropion hydrobromide has active ingredients of bupropion hydrobromide. It is often used in depression. eHealthMe is studying from 659 Bupropion hydrobromide users. Check the latest studies of Bupropion hydrobromide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

88 people who take Tramadol and Bupropion hydrobromide together, and have interactions are studied.

Tramadol and Bupropion hydrobromide drug interactions.

What are the common drug interactions of Tramadol and Bupropion Hydrobromide, by gender? *:

female:

Rhinitis allergic (inflammation of the nasal airways due to allergy)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Renal disorder (kidney disease)
Dyspnoea (difficult or laboured respiration)
Asthma
Wheezing (a high-pitched whistling sound made while you breath)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Burning sensation

male:

Anxiety
Chest discomfort
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Feeling jittery
Headache (pain in head)
Increased upper airway secretion
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

What are the common drug interactions of Tramadol and Bupropion Hydrobromide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Dyspnoea (difficult or laboured respiration)
Renal disorder (kidney disease)
Asthma
Wheezing (a high-pitched whistling sound made while you breath)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Burning sensation
Cardiac disorder

60+:

Headache (pain in head)
Bladder neoplasm (bladder tumour)
Renal failure (kidney dysfunction)
Sluggishness (lacking alertness)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Anxiety
Dizziness
Fatigue (feeling of tiredness)
Feeling jittery
Injection site erythema (redness at injection site)

What are the existing conditions these people have? *

Asthma: 35 people, 39.77%

* Approximation only. Some reports may have incomplete information.

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