Tramadol and Cometriq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Cometriq (cabozantinib s-malate). Common drug interactions include odynophagia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Cometriq. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,800 Tramadol users. Check the latest studies of Tramadol.

What is Cometriq?

Cometriq has active ingredients of cabozantinib s-malate. eHealthMe is studying from 2,712 Cometriq users. Check the latest studies of Cometriq.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

76 people who take Tramadol and Cometriq together, and have interactions are studied.

Tramadol and Cometriq drug interactions.

What are the common drug interactions of Tramadol and Cometriq, by gender? *:

female:

Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dyspepsia (indigestion)
Influenza
Malignant neoplasm progression (cancer tumour came back)
Drug intolerance (drug sensitivity)
Muscle spasms (muscle contraction)
Acne (skin problems that cause pimples)
Aptyalism (deficiency or absence of saliva)
Rash

male:

Diarrhoea
Fatigue (feeling of tiredness)
Decreased appetite
Dysphonia (speech disorder attributable to a disorder of phonation)
Headache (pain in head)
Abdominal discomfort
Asthenia (weakness)
Bone pain
Food intolerance (inability to have food)
Glossodynia (a burning or painful sensation in the tongue)

What are the common drug interactions of Tramadol and Cometriq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malignant neoplasm progression (cancer tumour came back)
Pericardial effusion malignant (cancerous fluid around the heart)
Death
Epistaxis (bleed from the nose)
Nausea (feeling of having an urge to vomit)
Rash

40-49:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hair colour changes
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)
Stomatitis (inflammation of mucous membrane of mouth)

50-59:

Decreased appetite
Asthenia (weakness)
Malignant neoplasm progression (cancer tumour came back)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Stomatitis (inflammation of mucous membrane of mouth)
Abdominal discomfort
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Asthenia (weakness)
Bone pain
Glossodynia (a burning or painful sensation in the tongue)
Headache (pain in head)
Myalgia (muscle pain)
Oral discomfort (pain or irritation in mouth)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Vomiting

What are the existing conditions these people have? *

Thyroid Cancer: 50 people, 65.79%
Renal Cell Carcinoma (a kidney cancer): 18 people, 23.68%
Metastases To Lymph Nodes (cancer spreads to lymph node): 7 people, 9.21%
Medullary Thyroid Cancer (type of thyroid cancer that develops in the parafollicular cells of the thyroid gland): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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