Tramadol and Divalproex sodium drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Divalproex sodium (divalproex sodium). Common drug interactions include headache among females and chronic kidney disease among males.
The phase IV clinical study analyzes what interactions people have when they take Tramadol and Divalproex sodium. It is created by eHealthMe based on reports of 283 people who take the same drugs from the FDA, and is updated regularly.
What is Tramadol?
Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.
What is Divalproex sodium?
Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.
283 people who take Tramadol and Divalproex sodium together, and have interactions are studied.

What are the common drug interactions of Tramadol and Divalproex sodium, by gender? *
What are the common drug interactions of Tramadol and Divalproex sodium, by age (0-1 to 60+)? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Tramadol and Divalproex sodium?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Tramadol (235,798 reports)
- Divalproex sodium (9,483 reports)
Browse all drug interactions of Tramadol and Divalproex sodium:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tramadol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Divalproex sodium:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tramadol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Divalproex sodium and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
- Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on tramadol hydrochloride and divalproex sodium (the active ingredients of Tramadol and Divalproex sodium, respectively), and Tramadol and Divalproex sodium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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